Evidence map›Paper›PMID 28059443›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2017

Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology.

Amy J Mikolajewski, Jeanette Taylor, William G Iacono

Abstract readTwin Study
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024
    Review
  4. Article
  5. Oppositional defiant disorder.Nature reviews. Disease primers · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. How and Why Are Irritability and Depression Linked?Child and adolescent psychiatric clinics of North America · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Oppositional defiant disorder: current insight.Psychology research and behavior management · 2017
    Review
  19. A Population-Based Twin Study of Childhood Irritability and Internalizing Syndromes.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amy J MikolajewskiDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Tulane University, New Orleans, LA, USA.
Jeanette TaylorDepartment of Psychology, Florida State University, Tallahassee, FL, USA.
William G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.

Funding

TWIN STUDY OF FEMALE ALCOHOLISMS AND OTHER DISORDERSR01AA009367 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1992 to 2013
$9.0M
Twin Family Study of Vulnerability to Substance AbuseR37DA005147 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2009 to 2018
$6.4M
TWIN/FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSER01DA005147 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G · 1987 to 2007
$5.5M
Adolescent drinking and midlife outcomes: A prospective cotwin control studyR37AA009367 · NIAAA · UNIVERSITY OF MINNESOTA · PI MCGUE, MATTHEW K. · 2016 to 2024
$5.4M
Adult consequences of youth substance use: Twin study enriched for SUD riskR01DA036216 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2013 to 2017
$3.2M
NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R37 AA009367NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA036216NIDA NIH HHS R37 DA005147
6 · The paper itself

Abstract

backgroundThis study was undertaken to determine how well two oppositional defiant disorder (ODD) dimensions (irritable and headstrong/hurtful) assessed in childhood predict late adolescent psychopathology and the degree to which these outcomes can be attributed to genetic influences shared with ODD dimensions.

methodsPsychopathology was assessed via diagnostic interviews of 1,225 twin pairs at ages 11 and 17.

resultsConsistent with hypotheses, the irritable dimension uniquely predicted overall internalizing problems, whereas the headstrong/hurtful dimension uniquely predicted substance use disorder symptoms. Both dimensions were predictive of antisocial behavior and overall externalizing problems. The expected relationships between the irritable dimension and specific internalizing disorders were not found. Twin modeling showed that the irritable and headstrong/hurtful dimensions were related to late adolescent psychopathology symptoms through common genetic influences.

conclusionsSymptoms of ODD in childhood pose a significant risk for various mental health outcomes in late adolescence. Further, common genetic influences underlie the covariance between irritable symptoms in childhood and overall internalizing problems in late adolescence, whereas headstrong/hurtful symptoms share genetic influences with substance use disorder symptoms. Antisocial behavior and overall externalizing share common genetic influences with both the irritable and headstrong/hurtful dimensions.

Indexed as

Adolescent BehaviorIrritable MoodAdolescentAttention Deficit and Disruptive Behavior DisordersChildChild Behavior DisordersFemaleHumansLongitudinal StudiesMaleMinnesotaRiskSubstance-Related DisordersenvironmentalgeneticlongitudinalOppositionalitysymptom dimensions

Identifiers

PMID28059443
PMCPMC5438275

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.