Evidence map›Paper›PMID 28059166›Full record

ArticleScientific reports2017

Mean Platelet Volume and Arterial Stiffness - Clinical Relationship and Common Genetic Variability.

Marina Panova-Noeva, Natalie Arnold, M Iris Hermanns, Jürgen H Prochaska, Andreas Schulz, Henri M Spronk, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Stefan Blankenberg and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Marina Panova-NoevaCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Natalie ArnoldCenter for Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
M Iris HermannsCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Jürgen H ProchaskaCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Andreas SchulzPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Henri M SpronkLaboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, The Netherlands.
Harald BinderInstitute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Norbert PfeifferDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Manfred BeutelDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Stefan BlankenbergDepartment of General and Interventional Cardiology, University Heart Centre, Hamburg-Eppendorf, Germany.
Tanja ZellerDepartment of General and Interventional Cardiology, University Heart Centre, Hamburg-Eppendorf, Germany.
Johannes LotzInstitute for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Thomas MünzelCenter for Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Karl J LacknerInstitute for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Hugo Ten CateLaboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, The Netherlands.
Philipp S WildCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
University Medical Center of the Johannes Gutenberg University Mainz · DEGerman Centre for Cardiovascular Research · DEJohannes Gutenberg University Mainz · DEMaastricht University · NLUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vessel wall stiffening is an important clinical parameter, but it is unknown whether platelets, key elements in the pathogenesis of arterial thrombosis, are associated with arterial stiffness. The present studies sought to determine whether mean platelet volume (MPV), a potential marker of platelet activation, is linked to vascular elasticity as assessed by the augmentation index (AIx), in 15,010 individuals from the population-based Gutenberg Health Study. Multivariable analysis showed that MPV in both males (β 0.776; 95

Indexed as

Genetic VariationMean Platelet VolumeVascular StiffnessBiomarkersCardiovascular DiseasesElasticityFemaleHumansKaplan-Meier EstimateMalePolymorphism, Single NucleotideRisk FactorsSex FactorsBiomarkers

Identifiers

PMID28059166
PMCPMC5216402
OpenAlexW2567943144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.