ArticleScientific reports2017
Conserved role of Ovo in germline development in mouse and Drosophila.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Photoreceptor control ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Article
- A fastFly · 2025Article
- Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis.Nature communications · 2025Article
- Review
- Female germline expression of OVO transcription factor bridges Drosophila generations.G3 (Bethesda, Md.) · 2025Article
- Transcriptional regulation of the piRNA pathway by Ovo in animal ovarian germ cells.Genes & development · 2025Article
- How germ granules promote germ cell fate.Nature reviews. Genetics · 2024Review
- OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in theeLife · 2024Article
- Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development.bioRxiv : the preprint server for biology · 2024Article
- OVO Positively Regulates Essential Maternal Pathways by Binding Near the Transcriptional Start Sites in thebioRxiv : the preprint server for biology · 2024Article
- OVOL2: an epithelial lineage determiner with emerging roles in energy homeostasis.Trends in cell biology · 2023Review
- Genomic signatures of recent convergent transitions to social life in spiders.Nature communications · 2022Article
- Ovo Like Zinc Finger 2 (OVOL2) Suppresses Breast Cancer Stem Cell Traits and Correlates with Immune Cells Infiltration.Breast cancer (Dove Medical Press) · 2022Article
- Offspring production from cryopreserved primordial germ cells in Drosophila.Communications biology · 2021Article
- Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos.Scientific reports · 2021Article
- Steroid-dependent switch of OvoL/Shavenbaby controls self-renewal versus differentiation of intestinal stem cells.The EMBO journal · 2021Article
- Myc plays an important role in Drosophila P-M hybrid dysgenesis to eliminate germline cells with genetic damage.Communications biology · 2020Article
- Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice.Reproductive biology and endocrinology : RB&E · 2019Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Ovo, which encodes a transcription factor with Zn-finger domains, is evolutionarily conserved among animals. In Drosophila, in addition to its zygotic function for egg production, maternal ovo activity is required in primordial germ cells (PGCs) for expression of germline genes such as vasa and nanos. In this study, we found that maternal Ovo accumulates in PGC nuclei during embryogenesis. In these cells, ovo serves a dual function: activation of genes expressed predominantly in PGCs, and conversely suppression of somatic genes. Reduction of ovo activity in PGCs makes them unable to develop normally into germ cells of both sexes. In mice, knockout of the ovo ortholog, Ovol2, which is expressed in PGCs, decreases the number of PGCs during early embryogenesis. These data strongly suggest that ovo acts as part of an evolutionarily conserved mechanism that regulates germline development in animals.
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