ArticleScientific reports2017
Scaling of titanium implants entrains inflammation-induced osteolysis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed.
- Extent of Implantoplasty in the Combined Surgical Therapy of Peri-Implantitis: A Quasi-Randomized Clinical Trial.Clinical implant dentistry and related research · 2026Trial
- Peri-implantitis reconstructive treatment implementing a titanium brush: 5-year extension results from a randomized clinical trial.Journal of periodontology · 2025Trial
- Assessment of titanium release following non-surgical peri-implantitis treatment: A randomized clinical trial.Journal of periodontology · 2023Trial
- Systemic antibiotic therapy as an adjunct to non-surgical peri-implantitis treatment: A single-blind RCT.Journal of clinical periodontology · 2021Trial
- A nonsurgical treatment of peri-implantitis using mechanic, antiseptic and anti-inflammatory treatment: 1 year follow-up.Clinical and experimental dental research · 2020Trial
- Biomechanical evaluation of implant materials and connection designs: a structured narrative review of titanium and zirconia.Odontology · 2026Review
- Implant-derived titanium particles impair macrophage bacterial clearance via TRPC1 and lysosomal dysfunction.PNAS nexus · 2026Article
- Modulation of the Immune-Inflammatory Microenvironment by Implant Material Properties in Peri-Implantitis.International journal of molecular sciences · 2026Review
- TRPV1-linked neuropeptide axes in periodontitis and peri-implantitis.Frontiers in endocrinology · 2026Review
- Titanium Dental Implant Corrosion in Peri-Implantitis and Implant Failure.Advances in experimental medicine and biology · 2026Review
- Immunological and tissue reactions to titanium particles generated by the mechanical decontamination of dental implants: In vitro and in vivo study.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Mucositis and Peri-Implant Disease Treatment with Chitosan and Titanium Brushes: A Systematic Review.Journal of clinical medicine · 2025Review
- DNA binding effects of LDH nanozyme for aseptic osteolysis mitigation through STING pathway modulation.Journal of nanobiotechnology · 2025Article
- Microbial Dysbiosis, Titanium Release, and Peri-implantitis.Journal of dental research · 2025Review
- Impact of High Insertion Torque on Implant Surface Integrity.Clinical implant dentistry and related research · 2025Article
- Titanium Particles Released from Dental Implants Under Fluoride Exposure Interact with Macrophages.Brazilian dental journal · 2025Article
- Peri-implantitis induction and resolution around zirconia versus titanium implants.Journal of periodontology · 2024Article
- Microvesicle-eluting nano-engineered implants influence inflammatory response of keratinocytes.Drug delivery and translational research · 2024Article
- Impact of Glow-Discharge Nitriding Technology on the Properties of 3D-Printed Grade 2 Titanium Alloy.Materials (Basel, Switzerland) · 2024Article
- Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids.Journal of nanobiotechnology · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Titanium discs with machined, sandblasted/acid-etched and sandblasted surfaces were subjected to ultrasonic scaling and we physically and chemically characterized the released particles. These particles induced a severe inflammatory response in macrophages and stimulated osteoclastogenesis. The number of released particles and their chemical composition and nanotopography had a significant effect on the inflammatory response. Sandblasted surfaces released the highest number of particles with the greatest nanoroughness properties. Particles from sandblasted/acid-etched discs induced a milder inflammatory response than those from sandblasted discs but a stronger inflammatory response than those from machined discs. Titanium particles were then embedded in fibrin membranes placed on mouse calvariae for 5 weeks. Using micro-CT, we observed that particles from sandblasted discs induced more osteolysis than those from sandblasted/acid-etched discs. In summary, ultrasonic scaling of titanium implants releases particles in a surface type-dependent manner and may aggravate peri-implantitis. Future studies should assess whether surface roughening affects the extent of released wear particles and aseptic loosening of orthopedic implants.
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