ArticleNano letters2017
Ultrasensitive Phototriggered Local Anesthesia.
Article in Nano letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Cooling-triggered sciatic nerve block using thermoresponsive hydrogel implants.Drug delivery and translational research · 2026Article
- Applications of micro/nano drug delivery systems in cancer pain management.Bioactive materials · 2026Review
- Design and Application of Intelligent Local Anesthetic Nanoformulations.Pharmaceutics · 2026Review
- Next-Generation Drug Delivery for Neurotherapeutics: The Promise of Stimuli-Triggered Nanocarriers.Biomedicines · 2025Review
- Emerging advances in drug delivery systems (DDSs) for optimizing cancer complications.Materials today. Bio · 2025Review
- Molecular Dynamics Insights into Peptide-Based Tetrodotoxin Delivery Nanostructures.Molecules (Basel, Switzerland) · 2024Article
- Methyl-Branched Liposomes as a Depot for Sustained Drug Delivery.Nano letters · 2023Article
- Aromatized liposomes for sustained drug delivery.Nature communications · 2023Article
- Assessing the Toxicity ofMarine drugs · 2023Article
- Hydration-induced Void-containing Hydrogels for Encapsulation and Sustained Release of Small Hydrophilic Molecules.Advanced functional materials · 2023Article
- Emerging Anesthetic Nanomedicines: Current State and Challenges.International journal of nanomedicine · 2023Review
- Emulsion-induced polymersomes taming tetrodotoxin for prolonged duration local anesthesia.Advanced therapeutics · 2023Article
- Intensity-adjustable pain management with prolonged duration based on phase-transitional nanoparticles-assisted ultrasound imaging-guided nerve blockade.Journal of nanobiotechnology · 2022Article
- Repetitive drug delivery using Light-Activated liposomes for potential antimicrobial therapies.Advanced drug delivery reviews · 2022Review
- Light-emitting diode phototherapy: pain relief and underlying mechanisms.Lasers in medical science · 2022Review
- Moderate-Intensity Ultrasound-Triggered On-Demand Analgesia Nanoplatforms for Postoperative Pain Management.International journal of nanomedicine · 2022Article
- Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel.Nature biomedical engineering · 2021Article
- Applications of capillary action in drug delivery.iScience · 2021Review
- Targeting drug delivery with light: A highly focused approach.Advanced drug delivery reviews · 2021Review
- Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near-infrared light mediated cancer therapy.Communications biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
An injectable local anesthetic producing repeatable on-demand nerve block would be desirable for pain management. Here we present a phototriggerable device to achieve repeatable and adjustable on-demand local anesthesia in superficial or deep tissues, consisting of gold nanorods attached to low temperature sensitive liposomes (LTSL). The particles were loaded with tetrodotoxin and dexmedetomidine. Near-infrared light (NIR, 808 nm, continuous wave) could heat gold nanorods at low fluence (short duration and low irradiance), leading to rapid release of payload. In vivo, 1-2 min of irradiation at ≤272 mW/cm
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.