Evidence map›Paper›PMID 28058797›Full record

ArticleInfluenza and other respiratory viruses2017

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007-2012.

Rachel Melanie Reeves, Pia Hardelid, Ruth Gilbert, Fiona Warburton, Joanna Ellis, Richard G Pebody

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Article in Influenza and other respiratory viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  12. Prevention of respiratory syncytial virus disease by immunisation.Archives of disease in childhood. Education and practice edition · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachel Melanie ReevesFarr Institute of Health Informatics Research, London, UK.ORCID 0000-0002-8949-1568
Pia HardelidFarr Institute of Health Informatics Research, London, UK.
Ruth GilbertFarr Institute of Health Informatics Research, London, UK.
Fiona WarburtonStatistics and Modelling Economics Department, Public Health England, Colindale, London, UK.
Joanna EllisVirus Reference Department, Public Health England, Colindale, London, UK.
Richard G PebodyRespiratory Diseases Department, Public Health England, Colindale, London, UK.

Funding

Arthritis Research UKBritish Heart FoundationCancer Research UKChief Scientist OfficeDepartment of Health PDF-2013-06-004Medical Research Council MR/K006584/1Wellcome Trust
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is a leading cause of hospital admission in young children. With several RSV vaccines candidates undergoing clinical trials, recent estimates of RSV burden are required to provide a baseline for vaccine impact studies.

objectivesTo estimate the number of RSV-associated hospital admissions in children aged <5 years in England over a 5-year period from 2007 using ecological time series modelling of national hospital administrative data. PATIENTS/

methodsMultiple linear regression modelling of weekly time series of laboratory surveillance data and Hospital Episode Statistics (HES) data was used to estimate the number of hospital admissions due to major respiratory pathogens including RSV in children <5 years of age in England from mid-2007 to mid-2012, stratified by age group (<6 months, 6-11 months, 1-4 years) and primary diagnosis: bronchiolitis, pneumonia, unspecified lower respiratory tract infection (LRTI), bronchitis and upper respiratory tract infection (URTI).

resultsOn average, 33 561 (95% confidence interval 30 429-38 489) RSV-associated hospital admissions in children <5 years of age occurred annually from 2007 to 2012. Average annual admission rates were 35.1 (95% CI: 32.9-38.9) per 1000 children aged <1 year and 5.31 (95% CI: 4.5-6.6) per 1000 children aged 1-4 years. About 84% (95% CI: 81-91%) of RSV-associated admissions were for LRTI. The diagnosis-specific burden of RSV-associated admissions differed significantly by age group.

conclusionsRSV remains a significant cause of hospital admissions in young children in England. Individual-level analysis of RSV-associated admissions is required to fully describe the burden by age and risk group and identify optimal prevention strategies.

Indexed as

Cost of IllnessBronchiolitisBronchitisChild, PreschoolEnglandFemaleHospitalizationHumansInfantMalePneumonia, ViralRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesRespiratory Tract InfectionsRespiratory Syncytial Virus VaccinesbronchiolitisbronchitischildEnglandhospital admissionspneumoniarespiratory syncytial virus

Identifiers

PMID28058797
PMCPMC5304572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.