Evidence map›Paper›PMID 28058676›Full record

ArticleDoklady. Biochemistry and biophysics2016

Enzymatic antioxidant system of endotheliocytes.

M G Sharapov, R G Goncharov, A E Gordeeva, V I Novoselov, O A Antonova, A K Tikhaze, V Z Lankin

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  4. Review
  5. Article
  6. Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins.Doklady. Biochemistry and biophysics · 2019
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

M G SharapovInstitute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.
R G GoncharovInstitute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.
A E GordeevaInstitute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.
V I NovoselovInstitute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.
O A AntonovaRussian Cardiology Research and Production Center, Russian Federation Ministry of Health, 3ya Cherepkovskaya ul. 15A, Moscow, 121552, Russia.
A K TikhazeRussian Cardiology Research and Production Center, Russian Federation Ministry of Health, 3ya Cherepkovskaya ul. 15A, Moscow, 121552, Russia.
V Z LankinRussian Cardiology Research and Production Center, Russian Federation Ministry of Health, 3ya Cherepkovskaya ul. 15A, Moscow, 121552, Russia. lankin@cardio.ru.
Institute of Cell Biophysics · RUInstitute of Experimental Cardiology · RUMinistry of Health of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is shown that endothelial cells from human umbilical vein have a reduced activity and gene expression of the "classic" antioxidant enzymes (Cu,Zn-superoxide dismutase, catalase, and Se-containing glutathione peroxidase). At the same time, a high expression level of peroxiredoxin genes was identified in the same endothelial cells, which obviously indicates the predominant involvement of these enzymes in protecting the endothelium from the damaging effect of free radical peroxidation.

Indexed as

CatalaseCells, CulturedEndothelial CellsErythrocytesGene ExpressionGlutathione PeroxidaseHumansReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionSuperoxide Dismutase-1Umbilical VeinsCatalaseGlutathione PeroxidaseSuperoxide Dismutase-1

Identifiers

PMID28058676
OpenAlexW2568176633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.