Evidence map›Paper›PMID 28058660›Full record

ArticleEJNMMI research2017

Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients.

Manon N G J A Braat, Hugo W de Jong, Beatrijs A Seinstra, Mike V Scholten, Maurice A A J van den Bosch, Marnix G E H Lam

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Guideline
  2. Quantitative imaging in medicine and surgery · 2026
    Article
  3. Article
  4. Article
  5. Trans-arterial Radioembolization Dosimetry in 2022.Cardiovascular and interventional radiology · 2022
    Review
  6. Review
  7. Article
  8. Hepatobiliary Scintigraphy and GlassDiagnostics (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Quantifying the effects of absorbed dose from radioembolisation on healthy liver function with [European journal of nuclear medicine and molecular imaging · 2020
    Article
  11. A Pilot Study on Hepatobiliary Scintigraphy to Monitor Regional Liver Function inJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Manon N G J A BraatDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. M.N.G.Braat-3@umcutrecht.nl.
Hugo W de JongDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Beatrijs A SeinstraDepartment of Radiology and Nuclear Medicine, Meander Medical Center, Amersfoort, The Netherlands.
Mike V ScholtenDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Maurice A A J van den BoschDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Marnix G E H LamDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
University Medical Center Utrecht · NLHeidelberg University · DEMeander Medisch Centrum · NLUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRoutine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improve patient selection and treatment planning. A case series will be presented to illustrate the potential of this technique. Hepatocellular carcinoma patients with cirrhosis (Child-Pugh A and B) underwent hepatobiliary scintigraphy pre- and 3 months post-radioembolization as part of a prospective study protocol, which was prematurely terminated because of limited accrual. Included patients were analysed together with their clinical, laboratory and treatment data.

resultsPretreatment-corrected

conclusionsHepatobiliary scintigraphy may be of added value during work-up for radioembolization, to estimate liver function reserve and its segmental distribution, especially in patients with underlying cirrhosis, for whom analysis of clinical and laboratory parameters may not be sufficient.

Indexed as

Hepatobiliary scintigraphyHepatotoxicityRadioembolizationYttrium-90

Identifiers

PMID28058660
PMCPMC5215993
OpenAlexW2571553866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.