ArticleInternational journal of computer assisted radiology and surgery2017
The numerical stability of transformation-based CT ventilation.
Article in International journal of computer assisted radiology and surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Patient-Reported Outcomes: Comparing Functional Avoidance and Standard Thoracic Radiation Therapy in Lung Cancer.JCO clinical cancer informatics · 2025Trial
- Evaluation of variables predicting PFT changes for lung cancer patients treated on a prospective 4DCT-ventilation functional avoidance clinical trial.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Trial
- Results of a Multi-Institutional Phase 2 Clinical Trial for 4DCT-Ventilation Functional Avoidance Thoracic Radiation Therapy.International journal of radiation oncology, biology, physics · 2022Trial
- Diagnoses of pulmonary embolism from non-contrast 4DCT using image processing-derived quantitative perfusion scores.npj biomedical innovations · 2026Article
- Predicting ventilation from single breathing phase non-contrast CT using Swin Transformers.Medical physics · 2026Article
- Hybrid method for estimating lung ventilation from CT by combining intensity and motion information.Medical physics · 2025Article
- Comprehensive clinical evaluation of novel 4DCT-based lung function imaging methods.Journal of applied clinical medical physics · 2025Article
- Perfusion estimation from dynamic non-contrast computed tomography using self-supervised learning and a physics-inspired U-net transformer architecture.International journal of computer assisted radiology and surgery · 2025Article
- Assessing the consistency of CT-based ventilation imaging under noise reduction processing with simulated quantum noise using a nonrigid alveoli phantom.Frontiers in radiology · 2025Article
- A review on functional lung avoidance radiotherapy plan for lung cancer.Frontiers in oncology · 2024Review
- Systematic Evaluation of the Impact of Lung Segmentation Methods on 4-Dimensional Computed Tomography Ventilation Imaging Using a Large Patient Database.International journal of radiation oncology, biology, physics · 2024Article
- Advances in CT-based lung function imaging for thoracic radiotherapy.Frontiers in oncology · 2024Review
- An analysis of the regional heterogeneity in tissue elasticity in lung cancer patients with COPD.Frontiers in medicine · 2023Article
- Innovations in thoracic imaging: CT, radiomics, AI and x-ray velocimetry.Respirology (Carlton, Vic.) · 2022Review
- Geodesic density regression for correcting 4DCT pulmonary respiratory motion artifacts.Medical image analysis · 2021Article
- Quantifying pulmonary perfusion from noncontrast computed tomography.Medical physics · 2021Article
- An assessment of the correlation between robust CT-derived ventilation and pulmonary function test in a cohort with no respiratory symptoms.The British journal of radiology · 2021Article
- Technical Note: On the spatial correlation between robust CT-ventilation methods and SPECT ventilation.Medical physics · 2020Article
- N-Phase Local Expansion Ratio for Characterizing Out-of-Phase Lung Ventilation.IEEE transactions on medical imaging · 2020Article
- Robust HU-based CT ventilation from an integrated mass conservation formulation.Medical physics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Computed tomography (CT)-derived ventilation imaging utilizes deformable image registration (DIR) to recover respiratory-induced tissue volume changes from inhale/exhale 4DCT phases. While current strategies for validating CT ventilation rely on analyzing its correlation with existing functional imaging modalities, the numerical stability of the CT ventilation calculation has not been characterized. PURPOSE: The purpose of this study is to examine how small changes in the DIR displacement field can affect the calculation of transformation-based CT ventilation.
methodsFirst, we derive a mathematical theorem, which states that the change in ventilation metric induced by a perturbation to single displacement vector is bounded by the perturbation magnitude. Second, we introduce a novel Jacobian constrained optimization method for computing user-defined CT ventilation images.
resultsUsing the Jacobian constrained method, we demonstrate that for the same inhale/exhale CT pair, it is possible to compute two DIR transformations that have similar spatial accuracies, but generate ventilation images with significantly different physical characteristics. In particular, we compute a CT ventilation image that perfectly correlates with a single-photon emission CT perfusion scan.
conclusionThe analysis and experiments indicate that while transformation-based CT ventilation is a promising modality, small changes in the DIR displacement field can result in large relative changes in the ventilation image. As such, approaches for improving the reproducibility of CT ventilation are still needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.