ArticleACS central science2016
Why Do Membranes of Some Unhealthy Cells Adopt a Cubic Architecture?
Article in ACS central science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Bioinspired periodic mesoporous tin oxides enable steady nonequilibrium chemical sensing for enhanced gas discrimination.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Biocompatible Glycopolymer-PLA Amphiphilic Hybrid Block Copolymers with Unique Self-Assembly, Uptake, and Degradation Properties.Biomacromolecules · 2024Article
- Article
- Article
- Article
- What is the Sugar Code?Chembiochem : a European journal of chemical biology · 2022Review
- Article
- Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Encoding biological recognition in a bicomponent cell-membrane mimic.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Silica cubosomes templated by a star polymer.RSC advances · 2019Article
- Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes.Biomacromolecules · 2019Article
- The stabilization of primitive bicontinuous cubic phases with tunable swelling over a wide composition range.Soft matter · 2019Article
- Bioactive cell-like hybrids from dendrimersomes with a human cell membrane and its components.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Microfluidics Synthesis of Gene Silencing Cubosomes.ACS nano · 2018Article
- From glycophenotyping by (plant) lectin histochemistry to defining functionality of glycans by pairing with endogenous lectins.Histochemistry and cell biology · 2018Review
- Dendrimersomes Exhibit Lamellar-to-Sponge Phase Transitions.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonlamellar lipid arrangements, including cubosomes, appear in unhealthy cells, e.g., when they are subject to stress, starvation, or viral infection. The bioactivity of cubosomes-nanoscale particles exhibiting bicontinuous cubic structures-versus more common vesicles is an unexplored area due to lack of suitable model systems. Here, glycodendrimercubosomes (GDCs)-sugar-presenting cubosomes assembled from Janus glycodendrimers by simple injection into buffer-are proposed as mimics of biological cubic membranes. The bicontinuous cubic GDC architecture has been demonstrated by electron tomography. The stability of these GDCs in buffer enabled studies on lectin-dependent agglutination, revealing significant differences compared with the vesicular glycodendrimersome (GDS) counterpart. In particular, GDCs showed an increased activity toward concanavalin A, as well as an increased sensitivity and selectivity toward two variants of banana lectins, a wild-type and a genetically modified variant, which is not exhibited by GDSs. These results suggest that cells may adapt under unhealthy conditions by undergoing a transformation from lamellar to cubic membranes as a method of defense.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.