More than skin deep? Potential nicotinamide treatment applications in chronic kidney transplant recipients.

Andrew G Bostom, Basma Merhi, Joanna Walker, Leslie Robinson-Bostom

Open access · hybridAbstract readReview

In one paragraph

Review in World journal of transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.7field-weighted citation impact, top 28% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

Skin cancer management-updates on Merkel cell carcinoma.Annals of translational medicine · 2018
Review
Meat Intake and the Dose of Vitamin BInternational journal of tryptophan research : IJTR · 2017
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew G BostomAndrew G Bostom, Division of Hypertension and Kidney Diseases, Department of Medicine, Rhode Island Hospital, Providence, RI 02903, United States.

Basma MerhiAndrew G Bostom, Division of Hypertension and Kidney Diseases, Department of Medicine, Rhode Island Hospital, Providence, RI 02903, United States.

Joanna WalkerAndrew G Bostom, Division of Hypertension and Kidney Diseases, Department of Medicine, Rhode Island Hospital, Providence, RI 02903, United States.

Leslie Robinson-BostomAndrew G Bostom, Division of Hypertension and Kidney Diseases, Department of Medicine, Rhode Island Hospital, Providence, RI 02903, United States.

Rhode Island Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-melanoma cutaneous carcinomas, or skin cancers, predominantly squamous cell carcinomas (SCCs), are the most common malignancies occurring in kidney transplant recipients (KTRs). Squamous cell carcinoma risk is dramatically elevated in KTRs, occurring at rates of up 45-250 times those reported in general populations. New non-melanoma skin cancers in KTRs with a prior non-melanoma skin cancer also develop at 3-times the rate reported in non-KTRs with the same clinical history. The unique aggressiveness of SCCs in KTRs increases patient morbidity, due to the high rate of new lesions requiring treatment, frequently surgical excision. Oral nicotinamide shows promise in the chemoprevention of the especially aggressive non-melanoma skin cancers which occur in KTRs. This benefit might be conferred

Indexed as

Kidney transplantationNiacinamidePhosphorusSkin neoplasms

Identifiers

PMID28058215

DOI10.5500/wjt.v6.i4.658

PMCPMC5175223

OpenAlexW2565377710

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.