ArticleBiomicrofluidics2016
On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood.
Article in Biomicrofluidics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Adaptive time modulation technique for multiplexed on-chip particle detection across scales.Optica · 2023Article
- Comparison of Illumination Methods for Flow-Through Optofluidic Biosensors.Micromachines · 2023Article
- Optical trapping assisted label-free and amplification-free detection of SARS-CoV-2 RNAs with an optofluidic nanopore sensor.Biosensors & bioelectronics · 2021Article
- Recent advances in integrated solid-state nanopore sensors.Lab on a chip · 2021Review
- Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection.IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2021Article
- Article
- Optofluidic Flow-Through Biosensor Sensitivity - Model and Experiment.Journal of lightwave technology : a joint IEEE/OSA publication · 2021Article
- Optical trapping assisted detection rate enhancement of single molecules on a nanopore optofluidic chip.Optica · 2019Article
- Integration of sample preparation and analysis into an optofluidic chip for multi-target disease detection.Lab on a chip · 2018Article
- Buried Rib SiOIEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2018Article
- Multi-channel velocity multiplexing of single virus detection on an optofluidic chip.Optics letters · 2018Article
- Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing.Biomedical optics express · 2018Article
- Optimized ARROW-Based MMI Waveguides for High Fidelity Excitation Patterns for Optofluidic Multiplexing.IEEE journal of quantum electronics · 2018Article
- Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis.Critical reviews in clinical laboratory sciences · 2018Review
- Microfluidic System for Detection of Viral RNA in Blood Using a Barcode Fluorescence Reporter and a Photocleavable Capture Probe.Analytical chemistry · 2017Article
- Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of Ebola virus.Biosensors & bioelectronics · 2017Article
- Optofluidic Amplification-free Multiplex Detection of Viral Hemorrhagic Fevers.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We have developed an optofluidic analysis system that processes biomolecular samples starting from whole blood and then analyzes and identifies multiple targets on a silicon-based molecular detection platform. We demonstrate blood filtration, sample extraction, target enrichment, and fluorescent labeling using programmable microfluidic circuits. We detect and identify multiple targets using a spectral multiplexing technique based on wavelength-dependent multi-spot excitation on an antiresonant reflecting optical waveguide chip. Specifically, we extract two types of melanoma biomarkers, mutated cell-free nucleic acids -BRAFV600E and NRAS, from whole blood. We detect and identify these two targets simultaneously using the spectral multiplexing approach with up to a 96% success rate. These results point the way toward a full front-to-back chip-based optofluidic compact system for high-performance analysis of complex biological samples.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.