ArticleGastroenterology research2016
Immunostaining Detection of Cytomegalovirus in Gastrointestinal Biopsies: Clinicopathological Correlation at a Large Academic Health System.
Article in Gastroenterology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Cytomegalovirus Colitis in a Patient With Ulcerative Colitis With Loss of Corticosteroid Response Upon Upadacitinib Initiation.Gastroenterology & hepatology · 2024Article
- Clinical Manifestation of Cytomegalovirus-Associated Protein-Losing Enteropathy in Children.Nutrients · 2023Article
- Cytomegalovirus Diseases of the Gastrointestinal Tract.Viruses · 2022Article
- Histologic features of colonic infections.Der Pathologe · 2022Review
- Cytomegalovirus cell tropism and clinicopathological characteristics in gastrointestinal tract of patients with HIV/AIDS.Diagnostic pathology · 2022Article
- Differential diagnosis and management of immune checkpoint inhibitor-induced colitis: A comprehensive review.World journal of experimental medicine · 2021Review
- Cytomegalovirus-Associated Nephrotic Syndrome in a Patient with Myasthenia Gravis Treated with Azathioprine: A Case Report.The American journal of case reports · 2021Article
- Investigation of Cytomegalovirus in Intestinal Tissue in a Country With High CMV Seroprevalence.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Cytomegalovirus Infection in an Adult Patient With Neuromyelitis Optica and Acute Hemorrhagic Rectal Ulcer: Case Report and Literature Review.Frontiers in immunology · 2020Review
- A Practical Review of Cytomegalovirus in Gastroenterology and Hepatology.Gastroenterology research and practice · 2019Review
- Cytomegalovirus infection in the setting of occult ulcerative colitis: case report and review of the literature.Journal of community hospital internal medicine perspectives · 2018Article
- Gastric Perforation in a 60-Year-Old Woman with CMV Gastritis and Amphetamine Abuse Led to Death.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytomegalovirus (CMV) infection can be asymptomatic in healthy individuals but may cause serious complications in immunocompromised patients. We investigated the clinicopathological correlation of CMV in gastrointestinal (GI) biopsies at our institute between January 1, 2013 and December 31, 2015.
methodsA total of 105 non-neoplastic GI biopsies tested positive for CMV by immunohistochemistry (IHC). The IHC results were stratified as "true positive" if > 2 cells stained, or "rare positive" if only 1 - 2 cells stained. Clinical information including comorbidities, serum CMV viral loads, and treatment was reviewed and correlated.
resultsOverall 1% of all GI biopsies were positive for CMV by immunostaining. The most frequently involved organ was colon, followed by esophagus, stomach, ileum and duodenum. When > 2 cells were stained positive, serum CMV viral loads were positive in 52.2%, negative in 17.2%, and not tested in 27.6% of cases. When only 1 - 2 cells stained positive, CMV viral loads were positive in 23.4%, negative in 25.5%, and not tested in 51.1% of cases. We further showed that clinical management of CMV differs based on both pathological findings and underlying diseases.
conclusionsThe role of CMV in GI biopsies remains controversial. We propose an algorithm of performing CMV immunostaining based on clinicopathological correlation.
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