ArticleWorld journal of gastroenterology2016
Clinical features of acute hepatitis E super-infections on chronic hepatitis B.
Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Low HBV replication does not aggravate disease progression in patients with superinfection with HEV.Scientific reports · 2025Article
- Immunogenicity and safety of HepE Hecolin® in chronic hepatitis B patients at clinically stable stage: An open-label study in China.Human vaccines & immunotherapeutics · 2025Article
- Vaccination Strategies and Research Gaps in Hepatitis E Virus for Special Populations.Vaccines · 2025Review
- Epidemiological and clinical impact of hepatitis E virus coinfection in chronic hepatitis B infected patients in Hebei, China.Frontiers in microbiology · 2025Article
- Cost-Effectiveness of Hepatitis E Vaccination Strategies among Patients with Chronic Liver Diseases in China: A Model-Based Evaluation.Vaccines · 2024Article
- HEV Infection in the Context of Prior HBV-Related Liver Injury: Case Series.Infectious disease reports · 2024Article
- Review
- A new dyslipidemia-based scoring model to predict transplant-free survival in patients with hepatitis E-triggered acute-on-chronic liver failure.Lipids in health and disease · 2023Article
- Review of clinical characteristics, immune responses and regulatory mechanisms of hepatitis E-associated liver failure.World journal of clinical cases · 2022Review
- Hepatitis E virus infection in high-risk populations in Osun State, Nigeria.One health (Amsterdam, Netherlands) · 2021Article
- Feasibility of controlling hepatitis E in Jiangsu Province, China: a modelling study.Infectious diseases of poverty · 2021Article
- Hepatitis E Virus Superinfection: an Underrecognized Trigger of Acute Hepatitis B Virus Flare.Cureus · 2021Article
- Advances in Hepatitis E Virus Biology and Pathogenesis.Viruses · 2021Review
- Hepatitis E virus re-infection accelerates hepatocellular carcinoma development and relapse in a patient with liver cirrhosis: A case report and review of literature.World journal of hepatology · 2020Article
- HEV and HBV Dual Infection: A Review.Journal of clinical and translational hepatology · 2020Review
- Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology.Open forum infectious diseases · 2020Article
- Prognostic Significance of End-Stage Liver Diseases, Respiratory Tract Infection, and Chronic Kidney Diseases in Symptomatic Acute Hepatitis E.Frontiers in cellular and infection microbiology · 2020Article
- Acute sporadic hepatitis E in the Zhejiang coastal area of China: a 14-year hospital-based surveillance study.Virology journal · 2019Article
- Acute hepatitis E superinfection leading to chronic hepatitis B reactivation.BMJ case reports · 2018Article
- Current advances in the elimination of hepatitis B in China by 2030.Frontiers of medicine · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the clinical features and risk factors for adverse outcomes in chronic hepatitis B (CHB) superimposed with hepatitis E virus (HEV).
methodsThis retrospective cohort study included 228 patients with acute HEV infection (showing clinical acute hepatitis symptomology and positivity for anti-HEV immunoglobulin M) with underlying CHB (confirmed by positivity for hepatitis B surface antigen and/or hepatitis B virus (HBV) DNA over 6 mo) who had been admitted to the Shanghai Public Health Clinical Center, which represents the regional tertiary hospital for infectious diseases in Shanghai city, China. Data for adverse outcomes were collected, and included severe liver diseases (defined as liver failure and/or acute liver decompensation) and liver-related mortality. Logistic regression modeling was performed to determine the risk factors for adverse outcomes.
resultsThe symptoms caused by superimposed acute hepatitis E (AHE) were much more severe in cirrhotic patients (
conclusionCHB-related cirrhosis and intermediate HBV DNA level were associated with severe disease in superinfected patients, and successful antiviral treatment might counter this outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.