ArticleScientific reports2017
The driving force of prophages and CRISPR-Cas system in the evolution of Cronobacter sakazakii.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Genome Mining ofPathogens (Basel, Switzerland) · 2025Article
- Bacteria exploit viral dormancy to establish CRISPR-Cas immunity.Cell host & microbe · 2025Article
- Characterization ofFrontiers in microbiology · 2025Article
- Characterization ofMicroorganisms · 2022Article
- Prophage Diversity AcrossFrontiers in microbiology · 2022Article
- Genomic Characterization ofFrontiers in microbiology · 2022Article
- Genome-Wide Identification and Analysis of Chromosomally Integrated Putative Prophages Associated with Clinical Klebsiella pneumoniae Strains.Current microbiology · 2021Article
- Profiling the Virulence and Antibiotic Resistance Genes ofFrontiers in microbiology · 2021Article
- Molecular Characterization ofFoods (Basel, Switzerland) · 2020Article
- Genotypic and antimicrobial resistance characterizations ofFood science & nutrition · 2020Article
- Characterization of integrated prophages within diverse species of clinical nontuberculous mycobacteria.Virology journal · 2020Article
- Article
- Prediction, Diversity, and Genomic Analysis of Temperate Phages Induced From Shiga Toxin-ProducingFrontiers in microbiology · 2019Article
- Selective Maintenance of Multiple CRISPR Arrays Across Prokaryotes.The CRISPR journal · 2018Article
- Novel Multidrug-Resistant Cronobacter sakazakii Causing Meningitis in Neonate, China, 2015.Emerging infectious diseases · 2018Article
- Screening and characterization of prophages in Desulfovibrio genomes.Scientific reports · 2018Article
- Reconstituting the History of Cronobacter Evolution Driven by Differentiated CRISPR Activity.Applied and environmental microbiology · 2018Article
- Genomic characterization of malonate positiveGut pathogens · 2018Article
- Comparative genomics of Australian and international isolates of Salmonella Typhimurium: correlation of core genome evolution with CRISPR and prophage profiles.Scientific reports · 2017Article
- Use of a Pan-Genomic DNA Microarray in Determination of the Phylogenetic Relatedness among Cronobacter spp. and Its Use as a Data Mining Tool to Understand Cronobacter Biology.Microarrays (Basel, Switzerland) · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cronobacter sakazakii is an important foodborne pathogens causing rare but life-threatening diseases in neonates and infants. CRISPR-Cas system is a new prokaryotic defense system that provides adaptive immunity against phages, latter play an vital role on the evolution and pathogenicity of host bacteria. In this study, we found that genome sizes of C. sakazakii strains had a significant positive correlation with total genome sizes of prophages. Prophages contributed to 16.57% of the genetic diversity (pan genome) of C. sakazakii, some of which maybe the potential virulence factors. Subtype I-E CRISPR-Cas system and five types of CRISPR arrays were found in the conserved site of C. sakazakii strains. CRISPR1 and CRISPR2 loci with high variable spacers were active and showed potential protection against phage attacks. The number of spacers from two active CRISPR loci in clinical strains was significant less than that of foodborne strains, it maybe a reason why clinical strains were found to have more prophages than foodborne strains. The frequently gain/loss of prophages and spacers in CRISPR loci is likely to drive the quick evolution of C. sakazakii. Our study provides a new insight into the co-evolution of phages and C. sakazakii.
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