ArticleScientific reports2017
The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Unaltered intrinsic functional brain architecture in young women with primary dysmenorrhea.Scientific reports · 2018Trial
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- An Overview of Endometriosis and Potential Pharmacogenetic Targets.Pharmaceutical research · 2026Review
- De novo post-COVID-19 chronic pain: a piece of information about risk factor and clinical features.Pain reports · 2025Article
- The Influence of the Menstrual Cycle on Electrical Thresholds for Sensory and Pain Perception: Implications for Exercise and Rehabilitation in Women With and Without Primary Dysmenorrhea-A Pilot Study.Healthcare (Basel, Switzerland) · 2025Article
- Reward system neurodynamics during menstrual pain modulated byFrontiers in molecular neuroscience · 2024Article
- Adaptive neuroplasticity in the default mode network contributing to absence of central sensitization in primary dysmenorrhea.Frontiers in neuroscience · 2023Article
- Scientific Knowledge Graph of Dysmenorrhea: A Bibliometric Analysis from 2001 to 2021.Journal of pain research · 2023Article
- Article
- Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction.Scientific reports · 2022Article
- Toward Composite Pain Biomarkers of Neuropathic Pain-Focus on Peripheral Neuropathic Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- A systems omics-based approach to decode substance use disorders and neuroadaptations.Neuroscience and biobehavioral reviews · 2021Review
- Post-Mastectomy Pain: An Updated Overview on Risk Factors, Predictors, and Markers.Life (Basel, Switzerland) · 2021Review
- Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine.Journal of translational medicine · 2021Article
- Polymorphisms of the μ-opioid receptor gene influence cerebral pain processing in fibromyalgia.European journal of pain (London, England) · 2021Article
- Sensitivity of functional connectivity to periaqueductal gray localization, with implications for identifying disease-related changes in chronic visceral pain: A MAPP Research Network neuroimaging study.NeuroImage. Clinical · 2020Article
- Bioinformatics Analysis of Genes and Mechanisms in Postherpetic Neuralgia.Pain research & management · 2020Article
- Article
- Experimental evaluation of central pain processes in young women with primary dysmenorrhea.Pain · 2019Article
- Psychology of Chronic Pelvic Pain: Prevalence, Neurobiological Vulnerabilities, and Treatment.Clinical obstetrics and gynecology · 2019Review
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Authors and funding
8 authors.
Funding
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Abstract
The mu-opioid receptor (OPRM1) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the OPRM1 A118G polymorphisms could provide a possible explanation for the differences in pain experience. Sixty-one subjects with PDM and 65 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; blood samples were taken for genotyping. We studied 3 aspects of pain experience, namely, mnemonic pain (recalled overall menstrual pain), present pain (spontaneous menstrual pain), and experimental pain (thermal pain) intensities. We report that G allele carriers, in comparison to AA homozygotes, exhibited functional hypo-connectivity between the anterior cingulate cortex (ACC) and periaqueductal gray (PAG). Furthermore, G allele carriers lost the correlation with spontaneous pain experience and exhibited dysfunctional DPMS by means of PAG-seeded FC dynamics. This OPRM1 A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience.
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