ArticleScientific reports2017
Atypical developmental trajectory of local spontaneous brain activity in autism spectrum disorder.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Atypical local brain connectivity in pediatric autism spectrum disorder? A coordinate-based meta-analysis of regional homogeneity studies.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- Altered Temporospatial Variability of Dynamic Amplitude of Low-Frequency Fluctuation in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Machine-learning classification of children and adolescents with ASD using resting-state frequency-specific intrinsic activity.Frontiers in neuroscience · 2026Article
- Atypical brain function hierarchy in autism spectrum disorder: insights from a novel analytical approach based on neuronal oscillation pattern.European child & adolescent psychiatry · 2025Article
- Contextual auditory processing in the inferior colliculus is affected in a sex- and age-dependent manner in the valproic acid-induced rat model of autism.PLoS biology · 2025Article
- Investigating Resting-State Brain Activity in Adolescents with High-Functioning Autism Spectrum Disorder: Linking Fractional Amplitude of Low-Frequency Fluctuation to Clinical Symptoms.Journal of autism and developmental disorders · 2025Article
- Alterations in Cerebral Intrinsic Activity in First-Episode, Drug-Naive Patients With Major Depressive Disorder.Cureus · 2025Article
- Effects of vitamin D on brain function in preschool children with autism spectrum disorder: a resting-state functional MRI study.BMC psychiatry · 2025Article
- Links between brain structure and function in children with autism spectrum disorder by parallel independent component analysis.Brain imaging and behavior · 2025Article
- Early identification of autism spectrum disorder in preschoolers by static and dynamic amplitude of low-frequency fluctuations features.Frontiers in human neuroscience · 2025Article
- Structural and functional coupling alterations in autism spectrum disorder with and without comorbid attention deficit hyperactivity disorder.Frontiers in psychiatry · 2025Article
- Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis.European child & adolescent psychiatry · 2024Article
- Functional brain network alterations in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.European child & adolescent psychiatry · 2024Article
- Reduced covariation between brain morphometry and local spontaneous activity in young children with ASD.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Utilizing typical developmental trajectories to reflect brain abnormalities in autism spectrum disorder.Psychoradiology · 2024Article
- Differences in the amplitude of low-frequency fluctuations of spontaneous brain activity between preterm and term infants.Frontiers in neurology · 2024Article
- Specific brain imaging alterations underlying autistic traits in children with attention-deficit/hyperactivity disorder.Behavioral and brain functions : BBF · 2023Article
- Abnormal spontaneous brain activity in females with autism spectrum disorders.Frontiers in neuroscience · 2023Article
- Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder.Molecular autism · 2022Article
- Mapping brain functional and structural abnormities in autism spectrum disorder: moving toward precision treatment.Psychoradiology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is marked by atypical trajectory of brain maturation, yet the developmental abnormalities in brain function remain unclear. The current study examined the effect of age on amplitude of low-frequency fluctuations (ALFF) in ASD and typical controls (TC) using a cross-sectional design. We classified all the participants into three age cohorts: child (<11 years, 18ASD/20TC), adolescent (11-18 years, 28ASD/26TC) and adult (≥18 years, 18ASD/18TC). Two-way analysis of variance (ANOVA) was performed to ascertain main effects and interaction effects on whole brain ALFF maps. Results exhibited significant main effect of diagnosis in ASD with decreased ALFF in the right precuneus and left middle occipital gyrus during all developmental stages. Significant diagnosis-by-age interaction was observed in the medial prefrontal cortex (mPFC) with ALFF lowered in autistic children but highered in autistic adolescents and adults. Specifically, remarkable quadratic change of ALFF with increasing age in mPFC presented in TC group was absent in ASD. Additionally, abnormal ALFF values in diagnosis-related brain regions predicted the social deficits in ASD. Our findings indicated aberrant developmental patterns of spontaneous brain activity associated with social deficits in ASD and highlight the crucial role of the default mode network in the development of disease.
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