ArticleScientific reports2017
Decreased empathy response to other people's pain in bipolar disorder: evidence from an event-related potential study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Meta-analysis of ERP investigations of pain empathy underlines methodological issues in ERP research.Social cognitive and affective neuroscience · 2018Pooled it
- Reciprocal changes in electrophysiological and behavioral metrics reflecting empathy impairment among adolescents with major depressive disorder.BMC psychiatry · 2026Article
- Exploring Pain Empathy Among Doctors, Nurses and Patients: A Scoping Review.Journal of multidisciplinary healthcare · 2025Review
- Effects of multidomain environmental and mental health factors on the development of empathetic behaviors and emotions in adolescence.PloS one · 2023Article
- The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy.Frontiers in psychology · 2022Article
- Competitive Intensity Modulates the Pain Empathy Response: An Event-Related Potentials Study.Frontiers in psychology · 2018Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
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Abstract
Bipolar disorder (BD) patients often demonstrate poor socialization that may stem from a lower capacity for empathy. We examined the associated neurophysiological abnormalities by comparing event-related potentials (ERP) between 30 BD patients in different states and 23 healthy controls (HCs, matched for age, sex, and education) during a pain empathy task. Subjects were presented pictures depicting pain or neutral images and asked to judge whether the person shown felt pain (pain task) and to identify the affected side (laterality task) during ERP recording. Amplitude of pain-empathy related P3 (450-550 ms) of patients versus HCs was reduced in painful but not neutral conditions in occipital areas [(mean (95% confidence interval), BD vs. HCs: 4.260 (2.927, 5.594) vs. 6.396 (4.868, 7.924)] only in pain task. Similarly, P3 (550-650 ms) was reduced in central areas [4.305 (3.029, 5.581) vs. 6.611 (5.149, 8.073)]. Current source density in anterior cingulate cortex differed between pain-depicting and neutral conditions in HCs but not patients. Manic severity was negatively correlated with P3 difference waves (pain - neutral) in frontal and central areas (Pearson r = -0.497, P = 0.005; r = -0.377, P = 0.040). Electrophysiological correlates of empathy processing are reduced in BD depending on manic symptom severity.
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