Evidence map›Paper›PMID 28057735›Full record

ArticleHaematologica2017

Increased age-associated mortality risk in HLA-mismatched hematopoietic stem cell transplantation.

Daniel Fürst, Dietger Niederwieser, Donald Bunjes, Eva M Wagner, Martin Gramatzki, Gerald Wulf, Carlheinz R Müller, Christine Neuchel, Chrysanthi Tsamadou, Hubert Schrezenmeier and 1 more

Abstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Frontiers in immunology · 2021
    Article
  3. Composite GRFS and CRFS Outcomes After Adult Alternative Donor HCT.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel FürstInstitute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, Ulm, Germany.
Dietger NiederwieserDepartment of Hematology/Oncology, University of Leipzig, Germany.
Donald BunjesDepartment of Internal Medicine III, University of Ulm, Germany.
Eva M WagnerDepartment of Medicine III, Johannes Gutenberg-University Mainz, Germany.
Martin GramatzkiDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine, University of Kiel, Germany.
Gerald WulfDepartment of Hematology/Oncology, Georg-August-University Göttingen, Germany.
Carlheinz R MüllerZKRD-Zentrales Knochenmarkspender-Register für Deutschland (German National Bone Marrow Donor Registry), Ulm, Germany.
Christine NeuchelInstitute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, Ulm, Germany.
Chrysanthi TsamadouInstitute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, Ulm, Germany.
Hubert SchrezenmeierInstitute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, Ulm, Germany.
Joannis MytilineosInstitute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg - Hessen, Ulm, Germany j.mytilineos@blutspende.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated a possible interaction between age-associated risk and HLA-mismatch associated risk on prognosis in different age categories of recipients of unrelated hematopoietic stem cell transplants (HSCT) (n=3019). Patients over 55 years of age transplanted with 8/10 donors showed a mortality risk of 2.27 (CI 1.70-3.03,

Indexed as

Hematopoietic Stem Cell TransplantationMortalityPublic Health SurveillanceUnrelated DonorsAdolescentAdultAgedAge FactorsFemaleHistocompatibilityHistocompatibility TestingHLA AntigensHumansKaplan-Meier EstimateMaleMiddle AgedHLA Antigens

Identifiers

PMID28057735
PMCPMC5395120

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.