ArticleGenome biology and evolution2017
Extremely Low Genomic Diversity of Rickettsia japonica Distributed in Japan.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genomic evolution and adaptation of arthropod-associated Rickettsia.Scientific reports · 2022Pooled it
- Epidemiological Survey of Tick-Borne Zoonotic Pathogens in Questing Ticks from the Qinghai-Tibetan Plateau of China.Animals : an open access journal from MDPI · 2026Article
- Pangenomic and genomic plasticity analyses of the genus Rickettsia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Systemic lupus erythematosus mimicking Japanese spotted fever due to Rickettsia japonica detection in an eschar: a case report.BMC infectious diseases · 2026Article
- Genetic diversity and host-symbiont cophylogenetic analysis ofCurrent research in parasitology & vector-borne diseases · 2026Article
- Sporadic Human Infections WithTransboundary and emerging diseases · 2025Observational
- Deleterious effects of a combination therapy using fluoroquinolones and tetracyclines for the treatment of Japanese spotted fever: a retrospective cohort study based on a Japanese hospital database.The Journal of antimicrobial chemotherapy · 2024Article
- Phylogenetic Analysis of Spotted Fever Group Rickettsia Gene from Ticks and Human Patients in Tottori Prefecture, Japan.Yonago acta medica · 2023Article
- Molecular detection reveals diverse tick-borne bacterial and protozoan pathogens in two tick species from Yingshan County of Hubei Province, China in 2021-2022.Frontiers in microbiology · 2023Article
- Molecular Survey of Vector-Borne Pathogens in Ticks, Sheep Keds, and Domestic Animals from Ngawa, Southwest China.Pathogens (Basel, Switzerland) · 2022Article
- Molecular Characterization by Multilocus Sequence Typing and Diversity Analysis ofVector borne and zoonotic diseases (Larchmont, N.Y.) · 2022Article
- The evolution of hard tick-borne relapsing fever borreliae is correlated with vector species rather than geographical distance.BMC ecology and evolution · 2021Article
- Diversity of spotted fever group rickettsiae and their association with host ticks in Japan.Scientific reports · 2019Article
- Genomic Features ofFrontiers in microbiology · 2019Article
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Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rickettsiae are obligate intracellular bacteria that have small genomes as a result of reductive evolution. Many Rickettsia species of the spotted fever group (SFG) cause tick-borne diseases known as "spotted fevers". The life cycle of SFG rickettsiae is closely associated with that of the tick, which is generally thought to act as a bacterial vector and reservoir that maintains the bacterium through transstadial and transovarial transmission. Each SFG member is thought to have adapted to a specific tick species, thus restricting the bacterial distribution to a relatively limited geographic region. These unique features of SFG rickettsiae allow investigation of how the genomes of such biologically and ecologically specialized bacteria evolve after genome reduction and the types of population structures that are generated. Here, we performed a nationwide, high-resolution phylogenetic analysis of Rickettsia japonica, an etiological agent of Japanese spotted fever that is distributed in Japan and Korea. The comparison of complete or nearly complete sequences obtained from 31 R. japonica strains isolated from various sources in Japan over the past 30 years demonstrated an extremely low level of genomic diversity. In particular, only 34 single nucleotide polymorphisms were identified among the 27 strains of the major lineage containing all clinical isolates and tick isolates from the three tick species. Our data provide novel insights into the biology and genome evolution of R. japonica, including the possibilities of recent clonal expansion and a long generation time in nature due to the long dormant phase associated with tick life cycles.
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