ArticleCerebral cortex (New York, N.Y. : 1991)2017
In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Cortical thickness abnormalities in autism spectrum disorder.European child & adolescent psychiatry · 2024Pooled it
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.NeuroImage. Clinical · 2021Pooled it
- The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD).Journal of psychopharmacology (Oxford, England) · 2019Trial
- Sex differences in trajectories of cortical development in autistic children from 2-13 years of age.Molecular psychiatry · 2024Article
- 3D CNN for neuropsychiatry: Predicting Autism with interpretable Deep Learning applied to minimally preprocessed structural MRI data.PloS one · 2024Article
- Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior.Molecular psychiatry · 2023Article
- Altered gray-to-white matter tissue contrast in preterm-born adults.CNS neuroscience & therapeutics · 2023Article
- Cortical gray-white matter contrast abnormalities in male children with attention deficit hyperactivity disorder.Frontiers in human neuroscience · 2023Article
- Learning to detect boundary information for brain image segmentation.BMC bioinformatics · 2022Article
- White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities.Molecular autism · 2022Article
- Cortical myelination in toddlers and preschoolers with autism spectrum disorder.Developmental neurobiology · 2022Article
- Increased functional connectivity of white-matter in myotonic dystrophy type 1.Frontiers in neuroscience · 2022Article
- Article
- Longitudinal Evaluation of Cerebral Growth Across Childhood in Boys and Girls With Autism Spectrum Disorder.Biological psychiatry · 2021Article
- Molecular Pathways within Autism Spectrum Disorder Endophenotypes.Journal of molecular neuroscience : MN · 2021Article
- Examining the Boundary Sharpness Coefficient as an Index of Cortical Microstructure in Autism Spectrum Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood.Human brain mapping · 2021Article
- Altered Gray-White Matter Boundary Contrast in Toddlers at Risk for Autism Relates to Later Diagnosis of Autism Spectrum Disorder.Frontiers in neuroscience · 2021Article
- Maturation of cortical microstructure and cognitive development in childhood and adolescence: A T1w/T2w ratio MRI study.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 7 countries.
Funding
Abstract
Atypical cortical organization and reduced integrity of the gray-white matter boundary have been reported by postmortem studies in individuals with autism spectrum disorder (ASD). However, there are no in vivo studies that examine these particular features of cortical organization in ASD. Hence, we used structural magnetic resonance imaging to examine differences in tissue contrast between gray and white matter in 98 adults with ASD and 98 typically developing controls, to test the hypothesis that individuals with ASD have significantly reduced tissue contrast. More specifically, we examined contrast as a percentage between gray and white matter tissue signal intensities (GWPC) sampled at the gray-white matter boundary, and across different cortical layers. We found that individuals with ASD had significantly reduced GWPC in several clusters throughout the cortex (cluster, P < 0.05). As expected, these reductions were greatest when tissue intensities were sampled close to gray-white matter interface, which indicates a less distinct gray-white matter boundary in ASD. Our in vivo findings of reduced GWPC in ASD are therefore consistent with prior postmortem findings of a less well-defined gray-white matter boundary in ASD. Taken together, these results indicate that GWPC might be utilized as an in vivo proxy measure of atypical cortical microstructural organization in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.