ReviewCurrent topics in developmental biology2017
Drosophila as a Model for Diabetes and Diseases of Insulin Resistance.
Review in Current topics in developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Sex-specific metabolic regulation by the Drosophila RNA-binding protein Nab2.bioRxiv : the preprint server for biology · 2026Article
- Modeling versatility as the hallmark of model organisms.History and philosophy of the life sciences · 2026Article
- Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels.Nature communications · 2026Article
- Metformin modulates survival, oxidative stress, and gene expression in a high-sucrose Drosophila diabetes model.PloS one · 2026Article
- Preclinical research in obesity-associated metabolic diseases using in vitro, multicellular, and non-mammalian models.Journal of physiology and biochemistry · 2025Review
- Combined supplementation of leucine and glutamine acts as a novel therapeutic approach to alleviate hyperglycemia and oxidative stress by targeting insulin signalling genes in a drosophila model of type 2 diabetes.Molecular biology reports · 2025Article
- Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms.RSC chemical biology · 2025Article
- Dual effects ofNarra J · 2025Article
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- Synthesis of a highly thermostable insulin by phenylalanine conjugation at B29 Lysine.Communications chemistry · 2024Article
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- A comprehensiveFrontiers in pharmacology · 2024Review
- Article
- Antidiabetes study ofJournal of Taibah University Medical Sciences · 2023Article
- A diabetes-like biochemical and behavioural phenotype ofProceedings. Biological sciences · 2023Article
- Article
- Inositol in Disease and Development: Roles of Catabolism viaInternational journal of molecular sciences · 2023Article
- Drosophila caspases as guardians of host-microbe interactions.Cell death and differentiation · 2023Review
- Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model.Molecules (Basel, Switzerland) · 2023Article
- Comparing the history of signalling pathway research using the research publication record of representative genes.microPublication biology · 2023Article
10 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Despite the importance of insulin signaling pathways in human disease, initial concerns that insect physiology and sugar metabolism differ enough from humans that flies would not model human disease hampered research in this area. However, during the past 10-15 years, evidence has accumulated that flies can indeed model various aspects of diabetes and related human disorders. This cluster of diseases impact insulin and insulin signaling pathways, fields which have been discussed in many excellent review articles in recent years. In this chapter, we restrict our focus to specific examples of diabetes-related disease models in Drosophila, discussing the advantages and limitations of these models in light of physiological similarities and differences between insects and mammals. We discuss features of metabolism and sugar regulation that are shared between flies and mammals, and specific Drosophila models for Type 1 and Type 2 diabetes, Metabolic syndrome, and related abnormalities including insulin resistance and heart disease. We conclude that fly models for diabetes and related disorders enhance our ability to identify genes and discern functional interactions that can be exploited for disease intervention.
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