Evidence map›Paper›PMID 28057070›Full record

ArticleActa neuropathologica communications2017

Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease.

Martina Barrenschee, Dimitri Zorenkov, Martina Böttner, Christina Lange, François Cossais, Amelie Bernadette Scharf, Günther Deuschl, Susanne A Schneider, Mark Ellrichmann, Annette Fritscher-Ravens and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Progress of Immunotherapies in Parkinson's Disease.CNS neuroscience & therapeutics · 2026
    Review
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  7. Article
  8. Article
  9. Review
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  11. The interrelationship between intestinal immune cells and enteric α-synuclein in the progression of Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Article
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  18. Microglia and Microbiome-Gut-Brain Axis.Advances in neurobiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Martina BarrenscheeInstitute of Anatomy, Kiel University, Kiel, Germany. m.barrenschee@anat.uni-kiel.de.
Dimitri ZorenkovDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Martina BöttnerInstitute of Anatomy, Kiel University, Kiel, Germany.
Christina LangeInstitute of Anatomy, Kiel University, Kiel, Germany.
François CossaisInstitute of Anatomy, Kiel University, Kiel, Germany.
Amelie Bernadette ScharfInstitute of Anatomy, Kiel University, Kiel, Germany.
Günther DeuschlDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Susanne A SchneiderDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Mark EllrichmannExperimental Endoscopy, Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Annette Fritscher-RavensExperimental Endoscopy, Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Thilo WedelInstitute of Anatomy, Kiel University, Kiel, Germany.
Kiel University · DEUniversity of Lübeck · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphorylated alpha-synuclein (p-α-syn) containing Lewy bodies (LBs) and Lewy neurites (LNs) are neuropathological hallmarks of Parkinson's disease (PD) in the central nervous system (CNS). Since they have been also demonstrated in the enteric nervous system (ENS) of PD patients, the aim of the study was to analyze enteric p-α-syn positive aggregates and intestinal gene expression. Submucosal rectal biopsies were obtained from patients with PD and controls and processed for dual-label-immunohistochemistry for p-α-syn and PGP 9.5. p-α-syn positive aggregates in nerve fibers and neuronal somata were subjected to a morphometric analysis. mRNA expression of α-syn and dopaminergic, serotonergic, VIP (vaso intestinal peptide) ergic, cholinergic, muscarinergic neurotransmitter systems were investigated using qPCR. Frequency of p-α-syn positive nerve fibers was comparable between PD and controls. Although neuronal p-α-syn positive aggregates were detectable in both groups, total number and area of p-α-syn positive aggregates were increased in PD patients as was the number of small and large sized aggregates. Increased expression of dopamine receptor D1, VIP and serotonin receptor 3A was observed in PD patients, while serotonin receptor 4 and muscarinic receptor 3 (M3R) were downregulated. M3R expression correlated negative with the number of small sized p-α-syn positive aggregates. The findings strengthen the hypothesis that the CNS pathology of increased p-α-syn in PD also applies to the ENS, if elaborated morphometry is applied and give further insights in altered intestinal gene expression in PD. Although the mere presence of p-α-syn positive aggregates in the ENS should not be regarded as a criterion for PD diagnosis, elaborated morphometric analysis of p-α-syn positive aggregates in gastrointestinal biopsies could serve as a suitable tool for in-vivo diagnosis of PD.

Indexed as

TranscriptomeAdultAgedAged, 80 and overalpha-SynucleinColonoscopyEnteric Nervous SystemGanglia, AutonomicGene Expression ProfilingHumansImmunohistochemistryMiddle AgedNeuronsParkinson DiseasePhosphorylationProtein Aggregation, Pathologicalalpha-SynucleinRNA, MessengerSNCA protein, humanEnteric nervous systemGastrointestinal biopsiesGene expressionParkinson’s diseasep-α-synuclein

Identifiers

PMID28057070
PMCPMC5217296
OpenAlexW2567972518

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.