ArticleVeterinary research2017
Congenital infection with atypical porcine pestivirus (APPV) is associated with disease and viral persistence.
Article in Veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 156 citations in OpenAlex.
- Characterization of Pestivirus scrofae infection in the tissues of a persistently infected boar.Porcine health management · 2026Article
- Viremia and antibody dynamics following atypical porcine pestivirus infection: a cohort study of pigs with congenital tremor.Porcine health management · 2026Article
- Transmission Dynamics of Gilts Persistently Infected with Atypical Porcine Pestivirus.Viruses · 2026Article
- Presence and shedding dynamics of Atypical Porcine Pestivirus (APPV) in semen of breeding boars: implications for virus transmission in pig production.BMC veterinary research · 2026Article
- Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture.Veterinary pathology · 2026Article
- Cerebellar hypomyelination, white matter vacuolization, and prolonged presence of atypical porcine pestivirus in pigs with congenital tremor type A-II.Veterinary pathology · 2026Article
- Evolution of Porcine Virus Isolation: Guidelines for Practical Laboratory Application.Microorganisms · 2025Review
- First detection and genetic characterization of atypical Porcine pestivirus in pigs, Thailand.Scientific reports · 2025Article
- Prevalence estimation of Pestivirus scrofae (atypical porcine pestivirus) among Hungarian pig herds and the effects of different sample types on detection rates.Porcine health management · 2025Article
- First detection of atypical porcine pestivirus in piglets affected by congenital tremor in Poland.Veterinary research communications · 2025Article
- Immunogenicity of subunit vaccine of E2 protein against atypical porcine pestivirus in pigs.Frontiers in cellular and infection microbiology · 2025Article
- Isolation and Phylogenetic Analysis of Atypical Porcine Pestivirus Isolates Identified in Russian Swine Herds.Viruses · 2024Article
- Enhancing the understanding of coinfection outcomes: Impact of natural atypical porcine pestivirus infection on porcine reproductive and respiratory syndrome in pigs.Virus research · 2024Article
- Article
- Development and application of an indirect ELISA for detection of antibodies against emerging atypical porcine pestivirus.Virology journal · 2024Article
- A Rapid and Novel Multiplex PCR Assay for Simultaneous Detection of Multiple Viruses Associated with Bovine Gastroenteritis.Indian journal of microbiology · 2023Article
- Genome characteristics of atypical porcine pestivirus from abortion cases in Shandong Province, China.Virology journal · 2023Article
- Isolation and artificial production of atypical porcine pestivirus, using the swine-kidney-derived cell line SK-L.Archives of virology · 2023Article
- Isolation and Molecular Characterization of Atypical Porcine Pestivirus Emerging in China.Viruses · 2023Article
- Screening for atypical porcine pestivirus in Swedish boar semen used for artificial insemination and a characterisation of the seminal RNA microbiome including the virome.BMC veterinary research · 2023Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2013, several Austrian piglet-producing farms recorded outbreaks of action-related repetitive myoclonia in newborn piglets ("shaking piglets"). Malnutrition was seen in numerous piglets as a complication of this tremor syndrome. Overall piglet mortality was increased and the number of weaned piglets per sow decreased by more than 10% due to this outbreak. Histological examination of the CNS of affected piglets revealed moderate hypomyelination of the white substance in cerebellum and spinal cord. We detected a recently discovered pestivirus, termed atypical porcine pestivirus (APPV) in all these cases by RT-PCR. A genomic sequence and seven partial sequences were determined and revealed a 90% identity to the US APPV sequences and 92% identity to German sequences. In confirmation with previous reports, APPV genomes were identified in different body fluids and tissues including the CNS of diseased piglets. APPV could be isolated from a "shaking piglet", which was incapable of consuming colostrum, and passaged on different porcine cells at very low titers. To assess the antibody response a blocking ELISA was developed targeting NS3. APPV specific antibodies were identified in sows and in PCR positive piglets affected by congenital tremor (CT). APPV genomes were detected continuously in piglets that gradually recovered from CT, while the antibody titers decreased over a 12-week interval, pointing towards maternally transmitted antibodies. High viral loads were detectable by qRT-PCR in saliva and semen of infected young adults indicating a persistent infection.
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