ArticleBMC complementary and alternative medicine2017
Antimalarial activity of Syzygium guineense during early and established Plasmodium infection in rodent models.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature.Malaria journal · 2021Pooled it
- Determination of total phenolic and flavonoid contents, antioxidant and antibacterial potential of the bark extracts of Syzygium guineense (Wild.) DC.BMC complementary medicine and therapies · 2025Article
- Medicinal plants administered to control hypertension in Ethiopia: ethnomedicine, pharmacology, nutraceutical, phytochemistry, toxicology, and policy perspectives.Frontiers in cardiovascular medicine · 2025Review
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- Toxic effect ofHeliyon · 2023Article
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- Countering Triple Negative Breast Cancer via Impeding Wnt/β-Catenin Signaling, a Phytotherapeutic Approach.Plants (Basel, Switzerland) · 2022Review
- Traditional uses, pharmacological activities, and phytochemical constituents of the genusFood science & nutrition · 2022Review
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- Prenatal Developmental Toxicity and Histopathological Changes of the Placenta Induced byJournal of toxicology · 2022Article
- Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract ofVeterinary medicine international · 2022Article
- Teratogenic Effect of High Dose ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Evaluation of the Antimalarial Activity of the Leaf Latex ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Sub-chronic toxicity of ethanol leaf extract ofToxicology reports · 2021Article
- Anti-Oxidant Potential and Antimalarial Effects ofJournal of experimental pharmacology · 2020Article
- Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Antimalarial Activity ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Antimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants.Journal of parasitology research · 2019Article
- Hematologic changes and splenic index on malaria mice models givenVeterinary world · 2019Article
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Abstract
backgroundIn Ethiopia, the leaves of Syzygium guineense have been found useful for the prevention and cure of malaria, and demonstrated antiplasmodial activity in vitro. Nevertheless, no scientific study has been conducted to confirm its antimalarial activity in vivo. Therefore, the objective of the study was to evaluate the antimalarial effect of Syzygium guineense leaf extract in mice.
methodsInoculation of the study mice was carried out by using the malaria parasite, Plasmodium berghei. The plant extract was prepared at 200, 400 and 600 mg/kg. Chloroquine and distilled water was administered to the positive and negative control groups respectively. Parameters like parasitaemia, survival time and body weight were determined following standard tests (4-day suppressive, Rane's and repository tests).
resultsSyzygium guineense crude leaf extract displayed considerable (p < 0.05) parasite suppression at doses of 600 and 400 mg/kg in a 4-day suppressive test with chemosuppressive value of 59.39 and 49.09% respectively. S. guineense crude leaf extract also showed dose-dependent schizontocidal activity in both the repository and curative tests. The extract also prevented body weight loss and prolonged survival date of mice significantly (P < 0.05) at the highest dose employed in the study. Qualitative chemical assay for S. guineense methanolic leaf extract revealed that the plant is endowed with different plant secondary metabolites exemplified by terpenoids, alkaloids, triterpenes, flavonoids, anthraquinones, tannins, glycosides, saponins and phenols.
conclusionSyzygium guineense leaf extract possess antimalarial activity in mice. The test substance was found to be safe with no observable signs of toxicity in the study mice. The results of the present work confirmed the in vitro antiplasmodial finding and traditional claims in vivo in mice. Therefore, Syzygium guineense could be regarded as a potential source to develop safe, effective and affordable antimalarial agent.
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