Evidence map›Paper›PMID 28056878›Full record

Trial reportBMC nephrology2017

Usefulness of measurement of heart rate variability by holter ECG in hemodialysis patients.

Nanami Kida, Yoshiharu Tsubakihara, Hirota Kida, Shunro Ageta, Makoto Arai, Yoshinosuke Hamada, Nariaki Matsuura

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. The cardiovascular unphysiology of thrice weekly hemodialysis.Current opinion in nephrology and hypertension · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Nanami KidaDepartment of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, 1-1 yamadaoka, 565-0871, Suita City, Osaka, Japan. nanami@cam.hi-ho.ne.jp.ORCID http://orcid.org/0000-0002-2717-1868
Yoshiharu TsubakiharaDepartment of Management in Health Care Sciences, Graduate School of Health Care Science, Jikei Institute, 1-2-8 miyahara yodogawaku, 532-0003, Osaka City, Japan.
Hirota KidaDepartment of Clinical Engineering, Osaka General medical Center, 3-1-56 bandaihigashi sumiyoshiku, 558-0056, Osaka City, Japan.
Shunro AgetaDepartment of Blood Purification Center, Nagahara Hospital, 4-3-13 nagatanishi, 577-0016, Higashiosaka City, Osaka, Japan.
Makoto AraiDepartment of Internal Medicine, Yuseikai Clinic, 10-39 hideincyo tennojiku, 543-0055, Osaka City, Japan.
Yoshinosuke HamadaDepartment of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, 1-1 yamadaoka, 565-0871, Suita City, Osaka, Japan.
Nariaki MatsuuraDepartment of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, 1-1 yamadaoka, 565-0871, Suita City, Osaka, Japan.
The University of Osaka · JPGraduate School of Health Care Sciences, Jikei Institute · JPHigashi Osaka City General Hospital · JPNobuhara Hospital · JPOsaka City General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor adverse cardiac and cerebrovascular event (MACCE) is one of most common complications of hemodialysis patients. Heart rate variability (HRV) is the predictor of death in heart disease patients. However, there are no studies on the role of HRV in hemodialysis patients.

methodsFrom September 2009 to March 2011, 24-h electrocardiography was performed in 101 hemodialysis patients. Standard deviation of sequential 5-minute N-N interval means (SDANN) and standard deviation of the N-N interval (SDNN) was examined by a 24-h ECG analysis. Patients were observed prospectively. The primary endpoints were incidence of MACCE and MACCE-free survival.

resultsWe studied 90 hemodialysis patients (64 males, 63.4 ± 11.8 years old). During a follow-up period of 32.0 ± 11.7 months, 33 patients developed MACCE. 24-h ECG showed mean SDNN 93.4 ± 33.4 ms and mean SDANN 83.2 ± 31.3 ms. MACCE group showed significantly lower SDNN and SDANN than event-free group. In Kaplan-Meier analysis higher SDNN and SDANN group showed significantly higher event-free survival rate than lower group. Using a Cox proportional hazards model, SDNN was independent prognostic factor while SDANN or diabetic status was not significant. In diabetic cases, there were no differences in any factors for the incidence of MACCE between higher SDNN, SDANN groups and lower groups. On the other hand in non-diabetic cases, lower SDNN or SDANN group developed significantly higher MACCE than higher groups.

conclusionMeasurement of HRV by Holter ECG is useful to predict MACCE in hemodialysis patients, especially non-diabetic group.

Indexed as

Cardiovascular DiseasesCausalityCerebrovascular DisordersComorbidityDisease-Free SurvivalElectrocardiography, AmbulatoryFemaleHeart RateHeart Rate DeterminationHumansIncidenceJapanMaleMiddle AgedRenal DialysisRenal Insufficiency, ChronicHeart rate variabilityHemodialysis patientsMajor adverse cardiac and cerebrovascular events

Identifiers

PMID28056878
PMCPMC5216586
OpenAlexW2569071546

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.