ArticleBMC cancer2017
Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies.
Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Primary cardiac angiosarcoma: From pathogenesis to therapeutic strategies.Medical oncology (Northwood, London, England) · 2026Review
- Mutational landscape of triple-negative breast cancer in African American women.Nature genetics · 2025Article
- Genomic landscape and preclinical models of angiosarcoma.Molecular oncology · 2025Review
- Review
- Advancements in Diagnosis and Treatment of Cardiac Sarcomas: A Comprehensive Review.Current treatment options in oncology · 2025Review
- Genomic Landscape Comparison of Cardiac versus Extra-Cardiac Angiosarcomas.Biomedicines · 2023Article
- Primary Cardiac Angiosarcoma: A Review.Cureus · 2023Review
- Cardiac angiosarcoma with multiple pulmonary metastases: A case report and literature review.Radiology case reports · 2023Article
- Analysis of the genomic landscapes of Barbadian and Nigerian women with triple negative breast cancer.Cancer causes & control : CCC · 2022Article
- Case reports by William C. Roberts, MD, and colleagues (1961-2022).Proceedings (Baylor University. Medical Center) · 2022Article
- Primary Soft Tissue Sarcoma of the Heart: An Emerging Chapter in Cardio-Oncology.Biomedicines · 2021Review
- Genetic aberrations and molecular biology of cardiac sarcoma.Therapeutic advances in medical oncology · 2020Review
- POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas.Journal of the American Heart Association · 2019Article
- The effect of ifosfamide, epirubicin, and recombinant human endostatin therapy on a cardiac angiosarcoma: A case report.Medicine · 2019Article
- A Case of Acute Lymphocytic Leukaemia with t(3;13) and Central Nervous System Leukemia after Allogenic Cord Blood Transplantation.Cell medicine · 2019Article
- Recurrent Cardiac Tamponade from Right Atrial Angiosarcoma.Chinese medical journal · 2018Article
- A Patient Presenting with Cardiac Tamponade and the Challenges of Finding Its Cause: A Cardiac Angiosarcoma.Case reports in cardiology · 2018Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary cardiac angiosarcomas are rare, but they are the most aggressive type of primary cardiac neoplasms. When patients do present, it is with advanced pulmonary and/or cardiac symptoms. Therefore, many times the correct diagnosis is not made at the time of initial presentation. These patients have metastatic disease and the vast majority of these patients die within a few months after diagnosis. Currently the treatment choices are limited and there are no targeted therapies available. CASE PRESENTATION: A 56-year-old male presented with shortness of breath, night sweats, and productive cough for a month. Workup revealed pericardial effusion and multiple bilateral pulmonary nodules suspicious for metastatic disease. Transthoracic echocardiogram showed a large pericardial effusion and a large mass in the base of the right atrium. Results of biopsy of bilateral lung nodules established a diagnosis of primary cardiac angiosarcoma. Aggressive pulmonary disease caused rapid deterioration; the patient went on hospice and subsequently died. Whole exome sequencing of the patient's postmortem tumor revealed a novel KDR (G681R) mutation, and focal high-level amplification at chromosome 1q encompassing MDM4, a negative regulator of TP53.
conclusionMutations in KDR have been reported previously in angiosarcomas. Previous studies also demonstrated that KDR mutants with constitutive KDR activation could be inhibited with specific KDR inhibitors in vitro. Thus, patients harboring activating KDR mutations could be candidates for treatment with KDR-specific inhibitors.
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