ArticleBMC cancer2017
Growth, progression and chromosome instability of Neuroblastoma: a new scenario of tumorigenesis?
Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Multimodal magnetic resonance imaging in neuroblastoma chemotherapy: a narrative review.World journal of surgical oncology · 2026Review
- LoRA-TV: read depth profile-based clustering of tumor cells in single-cell sequencing.Briefings in bioinformatics · 2024Article
- Analysis of High-Risk Neuroblastoma Transcriptome Reveals Gene Co-Expression Signatures and Functional Features.Biology · 2023Article
- Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance.Science advances · 2022Article
- Article
- Integrated CGH/WES Analyses Advance Understanding of Aggressive Neuroblastoma Evolution: A Case Study.Cells · 2021Article
- Gangliosides and Neuroblastomas.International journal of molecular sciences · 2020Review
- Systematic computational identification of prognostic cytogenetic markers in neuroblastoma.BMC medical genomics · 2019Article
- Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma.Molecular medicine reports · 2019Article
- Dissecting Intra-Tumor Heterogeneity by the Analysis of Copy Number Variations in Single Cells: The Neuroblastoma Case Study.International journal of molecular sciences · 2019Article
- Genomic clustering of fitness-affecting mutations favors the evolution of chromosomal instability.Evolutionary applications · 2019Article
- Neuroblastoma by chance.Journal of Cancer · 2019Article
- Chromosome instability in neuroblastoma.Oncology letters · 2018Review
- The Inhibitory Effect of Carboplatin Injection on Human Neuroblastoma SK-N-SH.Cell transplantationArticle
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuroblastoma is a pediatric cancer with a low survival rate of patients with metastatic stage 4 disease. Tumor aggressiveness and progression have been associated with structural copy number variations (CNVs) that are observed in malignant cells. In contrast, localized Neuroblastomas, which are associated with a low number of structural CNVs but frequent numerical CNVs, are less aggressive, and patients have good outcomes. Finally, whole-genome and whole-exome sequencing of Neuroblastoma tissues have shown few damaging mutations in these tumors.
conclusionsIn the present report it is proposed that chromosome instability (CIN) plays a major role in Neuroblastoma tumorigenesis and that CIN is already present in the early phases of tumor development. High CIN can promote several types of chromosomal damage including chromothripsis, gene deletion, amplification and rearrangements, which deregulate gene expression. Indeed, gene rearrangements have been reported as a new scenario in the development of Neuroblastoma, which supports the hypothesis that CIN is an early step preliminary to the late catastrophic events leading to tumor development.
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