Evidence map›Paper›PMID 28056487›Full record

ArticleMuscle & nerve2017

Non-invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography.

Benjamin Sanchez, Shama R Iyer, Jia Li, Kush Kapur, Su Xu, Seward B Rutkove, Richard M Lovering

Open access · greenAbstract readComparative Study
In one paragraph

Article in Muscle & nerve, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Wearable Bioelectronics for Home-Based Monitoring and Treatment of Muscle Atrophy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Electrical Impedance Methods in Neuromuscular Assessment: An Overview.Cold Spring Harbor perspectives in medicine · 2019
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Benjamin SanchezDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-1594-9847
Shama R IyerDepartment of Orthopaedics, University of Maryland School of Medicine, AHB, Room 540, 100 Penn Street, Baltimore, Maryland, 21201, USA.
Jia LiDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Kush KapurDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Su XuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Seward B RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Richard M LoveringDepartment of Orthopaedics, University of Maryland School of Medicine, AHB, Room 540, 100 Penn Street, Baltimore, Maryland, 21201, USA.
Beth Israel Deaconess Medical Center · USUniversity of Maryland, Baltimore · USBoston Children's Hospital · US

Funding

Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7M
Electrical Impedance Myography in an Animal ModelR01NS055099 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2007 to 2022
$5.1M
Mechanisms of Force Loss in Injured and Dystrophic Skeletal MuscleR01AR059179 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LOVERING, RICHARD M · 2010 to 2014
$1.4M
Targeting of cells to musculoskeletal injury via superparamagenetic nanoparticlesR21AR067872 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LOVERING, RICHARD M · 2016 to 2017
$373k
NIAMS NIH HHS R01 AR059179NIAMS NIH HHS R21 AR067872NIAMS NIH HHS T32 AR007592NINDS NIH HHS R01 NS055099
6 · The paper itself

Abstract

introductionDystrophic muscle is particularly susceptible to eccentric contraction-induced injury. We tested the hypothesis that electrical impedance myography (EIM) can detect injury induced by maximal-force lengthening contractions.

methodsWe induced injury in the quadriceps of wild-type (WT) and dystrophic (mdx) mice with eccentric contractions using an established model.

resultsmdx quadriceps had significantly greater losses in peak twitch and tetany compared with losses in WT quadriceps. Injured muscle showed a significant increase in EIM characteristic frequency in both WT (177 ± 7.7%) and mdx (167 ± 7.8%) quadriceps. EIM also revealed decreased extracellular resistance for both WT and mdx quadriceps after injury. DISCUSSION: Our results show overall agreement between muscle function and EIM measurements of injured muscle, indicating that EIM is a viable tool to assess injury in dystrophic muscle. Muscle Nerve 56: E85-E94, 2017.

Indexed as

Electric ImpedanceAnimalsMaleMiceMice, Inbred C57BLMice, Inbred mdxMuscle, SkeletalMuscular Dystrophy, DuchenneMyographyQuadriceps MuscleDuchenne muscular dystrophyedemaelectrical impedance myographyin-vivo injury

Identifiers

PMID28056487
PMCPMC5498260
OpenAlexW2571393205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.