ArticleBritish journal of cancer2017
The impact of age on complications, survival, and cause of death following colon cancer surgery.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Patterns of age disparities in colon and lung cancer survival: a systematic narrative literature review.BMJ open · 2021Pooled it
- Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery.BJS open · 2020Pooled it
- Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision.The lancet. Healthy longevity · 2022Trial
- Predictors of one and two years' mortality in patients with colon cancer: A prospective cohort study.PloS one · 2018Trial
- Risk factors for one-year mortality and the subsequent prognosis in older patients undergoing curative surgery for colorectal cancer: a retrospective multicenter study.Surgery today · 2026Article
- Older Age Does Not Have an Impact on Postoperative Complication Risk Following Transurethral Resection of the Bladder Tumor.Current oncology (Toronto, Ont.) · 2026Article
- Shifting paradigms in 30,427 surgical colorectal cancer cases (2008-2023): the impact of endoscopic screening on caseload complexity and the value of minimally invasive quality.Surgical endoscopy · 2026Article
- Article
- Age and Colorectal Cancer Outcomes: A Comparative Analysis Between Patients Younger and Older than 70 Years.Current oncology (Toronto, Ont.) · 2026Article
- Surgical Approach as a Mediator of Rural-Urban Disparity after Colon Cancer Resection.Journal of the American College of Surgeons · 2026Article
- Deconstructing Risk: A Machine Learning-Guided Logistic Regression Model for Predicting Early Mucosal Edema Following Prophylactic Ileostomy in Elderly Rectal Cancer Patients.International journal of general medicine · 2026Article
- Emergency colorectal cancer in old and very elderly patients: a narrative review.Frontiers in oncology · 2026Review
- Outcomes Following Colorectal Cancer Resection in Elderly Patients.Current oncology (Toronto, Ont.) · 2025Article
- Article
- Sex differences in the impact of multimorbidity on long-term mortality for patients with colorectal cancer: a population registry-based cohort study.Journal of public health (Oxford, England) · 2025Article
- Subclinical Atherosclerosis and Cardiovascular Events Among Patients With Colorectal Cancer.Cancer medicine · 2025Article
- Perspectives on prehabilitation for older adults with cancer: A report from the International Society of Geriatric Oncology (SIOG) rehabilitation group.Journal of geriatric oncology · 2025Article
- Investigating the molecular mechanism of vitexin targeting CDK1 to inhibit colon cancer cell proliferation via GEO chip data mining, computer simulation, and biological activity verification.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study.Diseases (Basel, Switzerland) · 2025Article
- Results of radical treatment of locally advanced rectal cancer in geriatric and non-geriatric patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGiven scarce data regarding the relationship among age, complications, and survival beyond the 30-day postoperative period for oncology patients in the United States, this study identified age-related differences in complications and the rate and cause of 1-year mortality following colon cancer surgery.
methodsThe NY State Cancer Registry and Statewide Planning and Research Cooperative System identified stage I-III colon cancer resections (2004-2011). Multivariable logistic regression and survival analyses assessed the relationship among age (<65, 65-74, ⩾75), complications, 1-year survival, and cause of death.
resultsAmong 24 426 patients surviving >30 days, 1-year mortality was 8.5%. Older age groups had higher complication rates, and older age and complications were independently associated with 1-year mortality (P<0.0001). Increasing age was associated with a decrease in the proportion of deaths from colon cancer with a concomitant increase in the proportion of deaths from cardiovascular disease. Older age and sepsis were independently associated with higher risk of colon cancer-specific death (65-74: HR=1.59, 95% CI=1.26-2.00; ⩾75: HR=2.57, 95% CI=2.09-3.16; sepsis: HR=2.58, 95% CI=2.13-3.11) and cardiovascular disease-specific death (65-74: HR=3.72, 95% CI=2.29-6.05; ⩾75: HR=7.02, 95% CI=4.44-11.10; sepsis: HR=2.33, 95% CI=1.81-2.99).
conclusionsOlder age and sepsis are associated with higher 1-year overall, cancer-specific, and cardiovascular-specific mortality, highlighting the importance of geriatric assessment, multidisciplinary care, and cardiovascular optimisation for older patients and those with infectious complications.
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