Evidence map›Paper›PMID 28056337›Full record

ArticleThe American journal of pathology2017

Marked Enteropathy in an Accelerated Macaque Model of AIDS.

Joshua D Croteau, Elizabeth L Engle, Suzanne E Queen, Erin N Shirk, M Christine Zink

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joshua D CroteauDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: jcrotea1@jhmi.edu.
Elizabeth L EngleDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Suzanne E QueenDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Erin N ShirkDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
M Christine ZinkDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · US

Funding

Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Barbara Stauch Slusher · 2006 to 2026
$33.2M
Project 4: Intracellular mechanism of virus persistence in astrocytes/macrophagesP01MH070306 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2004 to 2015
$16.0M
Viral Testing CoreU42OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2017 to 2026
$10.9M
Development of an SPF Macaca nemestrina Breeding ColonyP40OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI ADAMS, ROBERT J. · 2012 to 2016
$4.9M
Minocycline Immune Effects on SIV CNS DiseaseR01MH087233 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GRAHAM, DAVID R. M., ZINK, M CHRISTINE · 2010 to 2014
$3.0M
IDO Regulation in the SIV Model of HIV CNS DiseaseR01MH085554 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ZINK, M CHRISTINE · 2009 to 2013
$2.9M
NIH HHS P40 OD013117NIH HHS U42 OD013117NIMH NIH HHS P01 MH070306NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH085554NIMH NIH HHS R01 MH087233
6 · The paper itself

Abstract

Enteropathy in HIV infection is not eliminated with combination antiretroviral therapy and is possibly linked to microbial translocation. We used a rapidly progressing SIV/pigtailed macaque model of HIV to examine enteropathy and microbial translocation. Histologic evidence of intestinal disease was observed in only half of infected macaques during late-stage infection (LSI). Combination antiretroviral therapy initiated during acute infection prevented intestinal disease. In the ileum and colon, enteropathy was associated with increased caspase-3 staining, decreased CD3

Indexed as

Acquired Immunodeficiency SyndromeAcute DiseaseAnimalsAntigens, CDAntiretroviral Therapy, Highly ActiveCaspase 3Claudin-3ColonDisease Models, AnimalDrug Therapy, CombinationEpithelial CellsHIV EnteropathyIleumImmunohistochemistryIntestinesMacaca mulattaAntigens, CDCaspase 3Claudin-3Poly(A)-Binding Proteins

Identifiers

PMID28056337
PMCPMC5389367
OpenAlexW2570607030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.