ArticleJournal of biomedical optics2017
Evaluating anesthetic protocols for functional blood flow imaging in the rat eye.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed.
- Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.Biomedical optics express · 2026Article
- Effects of different anesthetic drugs on electroretinography in mice.Scientific reports · 2025Article
- Anesthetic effects on electrophysiological responses across the visual pathway.Scientific reports · 2024Article
- Connexin 50 Influences the Physiological Optics of the In Vivo Mouse Lens.Investigative ophthalmology & visual science · 2024Article
- Age-Dependent Changes in the Water Content and Optical Power of the In Vivo Mouse Lens Revealed by Multi-Parametric MRI and Optical Modeling.Investigative ophthalmology & visual science · 2023Article
- Opening a window to the acutely injured brain: Simultaneous retinal and cerebral vascular monitoring in rats.Frontiers in molecular neuroscience · 2023Article
- Choroidal Thickness in Early Postnatal Guinea Pigs Predicts Subsequent Naturally Occurring and Form-Deprivation Myopia.Investigative ophthalmology & visual science · 2022Article
- Measuring hyperemic response to light flicker stimulus using continuous laser speckle flowgraphy in mice.Experimental eye research · 2022Article
- Comparisons of α2-Adrenergic Agents, Medetomidine and Xylazine, with Pentobarbital for Anesthesia: Important Pitfalls in Diabetic and Nondiabetic Rats.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2022Article
- Intrinsic signal optoretinography of dark adaptation kinetics.Scientific reports · 2022Article
- Methods to measure blood flow and vascular reactivity in the retina.Frontiers in medicine · 2022Review
- In-vivo assessment of retinal vessel diameters and observer variability in mice: A methodological approach.PloS one · 2022Article
- Concurrent OCT and OCT angiography of retinal neurovascular degeneration in the 5XFAD Alzheimer's disease mice.Neurophotonics · 2021Article
- Retrobulbar blood flow in rat eyes during acute elevation of intraocular pressure.Experimental eye research · 2021Article
- Longitudinal Testing of Retinal Blood Flow in a Mouse Model of Hypertension by Laser Speckle Flowgraphy.Translational vision science & technology · 2021Article
- Vascular Reactivity to Hypercapnia Is Impaired in the Cerebral and Retinal Vasculature in the Acute Phase After Experimental Subarachnoid Hemorrhage.Frontiers in neurology · 2021Article
- Intravenous ketamine for long term anesthesia in rats.Heliyon · 2020Article
- Altered Retinal Hemodynamics and Mean Circulation Time in Spontaneously Hypertensive Rats.Investigative ophthalmology & visual science · 2020Article
- Multi-parametric MRI of the physiology and optics of the in-vivo mouse lens.Magnetic resonance imaging · 2020Article
- Correlation between adolescent chronic emotional stress and incidence of adult cardiovascular disease in female rats.Iranian journal of basic medical sciences · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The purpose of this study is to evaluate the suitability of five different anesthetic protocols (isoflurane, isoflurane–xylazine, pentobarbital, ketamine–xylazine, and ketamine–xylazine–vecuronium) for functional blood flow imaging in the rat eye. Total retinal blood flow was measured at a series of time points using an ultrahigh-speed Doppler OCT system. Additionally, each anesthetic protocol was qualitatively evaluated according to the following criteria: (1) time-stability of blood flow, (2) overall rate of blood flow, (3) ocular immobilization, and (4) simplicity. We observed that different anesthetic protocols produced markedly different blood flows. Different anesthetic protocols also varied with respect to the four evaluated criteria. These findings suggest that the choice of anesthetic protocol should be carefully considered when designing and interpreting functional blood flow studies in the rat eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.