ArticlePloS one2017
Postural Ataxia in Cerebellar Downbeat Nystagmus: Its Relation to Visual, Proprioceptive and Vestibular Signals and Cerebellar Atrophy.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Quantitative Oculomotor Assessment in Hereditary Ataxia: Systematic Review and Consensus by the Ataxia Global Initiative Working Group on Digital-motor Biomarkers.Cerebellum (London, England) · 2024Pooled it
- Long-term response to aminopyridines in a cohort of patients with ataxia associated with downbeat nystagmus due to the FGF14 GAA expansion.Neurologia · 2026Article
- Vestibular and visual influence on postural stability and egomotion perception in persistent postural-perceptual dizziness (PPPD).Journal of neurology · 2026Article
- Postural motion perception during vestibular stimulation depends on the motion perception threshold in persistent postural-perceptual dizziness.Journal of neurology · 2024Article
- Vestibulo-spatial navigation: pathways and sense of direction.Journal of neurophysiology · 2023Article
- Downbeat nystagmus becomes attenuated during walking compared to standing.Journal of neurology · 2022Article
- Impaired Lower Limb Proprioception in Spinocerebellar Ataxia Type 3 and Its Affected Factors.Frontiers in neurology · 2022Article
- Effects of perceptible and imperceptible galvanic vestibular stimulation on the postural control of patients with bilateral vestibulopathy.Journal of neurology · 2020Article
- [Research advances on mechanism and lesion location of vertical nystagmus].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Towards computerized diagnosis of neurological stance disorders: data mining and machine learning of posturography and sway.Journal of neurology · 2019Article
- Increase in weighting of vision vs. proprioception associated with force field adaptation.Scientific reports · 2019Article
- Postural control during galvanic vestibular stimulation in patients with persistent perceptual-postural dizziness.Journal of neurology · 2019Article
- Postural control during recall of vestibular sensation in patients with functional dizziness and unilateral vestibulopathy.Journal of neurology · 2017Article
- Postural Control in Bilateral Vestibular Failure: Its Relation to Visual, Proprioceptive, Vestibular, and Cognitive Input.Frontiers in neurology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cerebellum integrates proprioceptive, vestibular and visual signals for postural control. Cerebellar patients with downbeat nystagmus (DBN) complain of unsteadiness of stance and gait as well as blurred vision and oscillopsia.
objectivesThe aim of this study was to elucidate the differential role of visual input, gaze eccentricity, vestibular and proprioceptive input on the postural stability in a large cohort of cerebellar patients with DBN, in comparison to healthy age-matched control subjects.
methodsOculomotor (nystagmus, smooth pursuit eye movements) and postural (postural sway speed) parameters were recorded and related to each other and volumetric changes of the cerebellum (voxel-based morphometry, SPM).
resultsTwenty-seven patients showed larger postural instability in all experimental conditions. Postural sway increased with nystagmus in the eyes closed condition but not with the eyes open. Romberg's ratio remained stable and was not different from healthy controls. Postural sway did not change with gaze position or graviceptive input. It increased with attenuated proprioceptive input and on tandem stance in both groups but Romberg's ratio also did not differ. Cerebellar atrophy (vermal lobule VI, VIII) correlated with the severity of impaired smooth pursuit eye movements of DBN patients.
conclusionsPostural ataxia of cerebellar patients with DBN cannot be explained by impaired visual feedback. Despite oscillopsia visual feedback control on cerebellar postural control seems to be preserved as postural sway was strongest on visual deprivation. The increase in postural ataxia is neither related to modulations of single components characterizing nystagmus nor to deprivation of single sensory (visual, proprioceptive) inputs usually stabilizing stance. Re-weighting of multisensory signals and/or inappropriate cerebellar motor commands might account for this postural ataxia.
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