ArticlePLoS pathogens2017
Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
125 citing papers in PubMed, 188 citations in OpenAlex.
- Host-microbiota-pathogen interactions drive Salmonella enterica serovar Typhimurium pathogenesis.Nature reviews. Microbiology · 2026Review
- Salmonella infection and biofilms drive anti-C1q and anti-dsDNA autoantibodies in systemic autoimmunity.PLoS pathogens · 2026Article
- Gut Microbiota Signatures Associated with Metastatic Prostatic Cancer Treated with Androgen Receptor Pathway Inhibitor (ARPI) Therapy.International journal of molecular sciences · 2026Article
- Interbacterial AI-2 signaling orchestrates chemotaxis, attachment, and antimicrobial peptide resistance to promoteiScience · 2026Article
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- Comparative metagenomic and untargeted metabolomic analyses reveal gut microbiota and metabolite alterations associated with diarrhea in neonatal Holstein calves in Anhui, China.Veterinary world · 2026Article
- Gut microbiome mediates the association between dietary quality and metabolic risk in a heterogeneous adult population.Nutrition & metabolism · 2026Article
- Infection strategies ofGut microbes reports · 2026Review
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- Harnessing gut microbiota to mitigateVirulence · 2025Review
- Revisiting the gene loss of respiratory requirements for Salmonella Typhimurium and Salmonella Enteritidis in the chicken infection model.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model.Microbiome · 2025Article
- Temperature abuse and Salmonella Typhimurium colonization disrupt the indigenous bacterial communities of pasteurized bovine milk over time.Scientific reports · 2025Article
- Commensal resilience: ancient ecological lessons for the modern microbiota.Infection and immunity · 2025Review
- Enterohemorrhagic E. coli (EHEC) and the microbiome.PLoS pathogens · 2025Article
- Strain-specific galactose utilization by commensal E. coli mitigates Salmonella establishment in the gut.PLoS pathogens · 2025Article
- Bacterial microcompartments and energy metabolism drive gut colonization by Bilophila wadsworthia.Nature communications · 2025Article
- Whole-Genome Sequence Reveals Genetic Determinants of the Colonization of Shiga Toxin-Producing Escherichia coli O22:H8 Isolates in Cattle.Current microbiology · 2025Article
- Monosaccharides drive Salmonella gut colonization in a context-dependent or -independent manner.Nature communications · 2025Article
- Polarity effects, resistance, and probiotic enhancement of intoxication of Salmonella enterica fraB mutants in murine models.PloS one · 2025Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Intestinal inflammation caused by Salmonella enterica serovar Typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. Here we show that one of the carbon sources driving this respiratory expansion in the mouse model is 1,2-propanediol, a microbial fermentation product. 1,2-propanediol utilization required intestinal inflammation induced by virulence factors of the pathogen. S. Typhimurium used both aerobic and anaerobic respiration to consume 1,2-propanediol and expand in the murine large intestine. 1,2-propanediol-utilization did not confer a benefit in germ-free mice, but the pdu genes conferred a fitness advantage upon S. Typhimurium in mice mono-associated with Bacteroides fragilis or Bacteroides thetaiotaomicron. Collectively, our data suggest that intestinal inflammation enables S. Typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.