ArticlePloS one2017
Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- Cnpy1 is a candidate endoplasmic reticulum chaperone of vomeronasal type 2 GPCRs.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effects of silybin on triptorelin-induced bone metabolic abnormalities in prostate cancer revealed based on TMT-based proteomics.PloS one · 2026Article
- Physiochemical and transcriptomics of exotic holstein friesian cattle in Pakistani subtropics.Tropical animal health and production · 2025Article
- Integrated bioinformatic analysis of immune infiltration and disulfidptosis related gene subgroups in type A aortic dissection.Scientific reports · 2025Article
- CCDC134 controls TLR biogenesis through the ER chaperone Gp96.The Journal of experimental medicine · 2025Article
- Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94-Selective Ligand Binding.Proteins · 2025Article
- Genome-Wide Analysis of Sheep Artificially or Naturally Infected with Gastrointestinal Nematodes.Genes · 2023Article
- VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites.Developmental cell · 2022Article
- Active nNOS Is Required for Grp94-Induced Antioxidant Cytoprotection: A Lesson from Myogenic to Cancer Cells.International journal of molecular sciences · 2022Article
- Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing.Nature communications · 2021Article
- Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle.Science advances · 2021Article
- Chemical Biology Framework to Illuminate Proteostasis.Annual review of biochemistry · 2020Review
- Thermotolerance and plasticity of camel somatic cells exposed to acute and chronic heat stress.Journal of advanced research · 2020Article
- TMT-Based Proteomic Analysis of Plasma from Children with Rolandic Epilepsy.Disease markers · 2020Article
- Characterization of CNPY5 and its family members.Protein science : a publication of the Protein Society · 2019Article
- Mechanisms protecting host cells against bacterial pore-forming toxins.Cellular and molecular life sciences : CMLS · 2019Review
- Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.Journal of medicinal chemistry · 2018Article
- Article
- Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.The Journal of biological chemistry · 2017Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
Abstract
Up to 10% of cytosolic proteins are dependent on the mammalian heat shock protein 90 (HSP90) for folding. However, the interactors of its endoplasmic reticulum (ER) paralogue (gp96, Grp94 and HSP90b1) has not been systematically identified. By combining genetic and biochemical approaches, we have comprehensively mapped the interactome of gp96 in macrophages and B cells. A total of 511 proteins were reduced in gp96 knockdown cells, compared to levels observed in wild type cells. By immunoprecipitation, we found that 201 proteins associated with gp96. Gene Ontology analysis indicated that these proteins are involved in metabolism, transport, translation, protein folding, development, localization, response to stress and cellular component biogenesis. While known gp96 clients such as integrins, Toll-like receptors (TLRs) and Wnt co-receptor LRP6, were confirmed, cell surface HSP receptor CD91, TLR4 pathway protein CD180, WDR1, GANAB and CAPZB were identified as potentially novel substrates of gp96. Taken together, our study establishes gp96 as a critical chaperone to integrate innate immunity, Wnt signaling and organ development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.