Evidence map›Paper›PMID 28056024›Full record

Trial reportPLoS neglected tropical diseases2017

A Double-Blind Randomized Controlled Trial of Maternal Postpartum Deworming to Improve Infant Weight Gain in the Peruvian Amazon.

Layla S Mofid, Martín Casapía, Eder Aguilar, Hermánn Silva, Antonio Montresor, Elham Rahme, William D Fraser, Grace S Marquis, Jozef Vercruysse, Lindsay H Allen and 4 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01748929 (Postpartum Deworming), which is not on this map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01748929 phase4completednot on this map

Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth

TypeinterventionalSponsorMcGill University Health Centre/Research Institute of the McGill University Health CentreRan2014 to 2016Enrolled1,010ConditionsIntestinal Diseases, ParasiticArmsAlbendazole, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 5 countries.

Layla S MofidDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.
Martín CasapíaAsociación Civil Selva Amazónica, Iquitos, Peru.
Eder AguilarHospital Iquitos "César Garayar García", Iquitos, Peru.
Hermánn SilvaHospital Iquitos "César Garayar García", Iquitos, Peru.
Antonio MontresorDepartment of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Elham RahmeDivision of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
William D FraserCentre de recherche et Département d'obstétrique et de gynécologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Grace S MarquisSchool of Dietetics and Human Nutrition, McGill University, Ste. Anne-de-Bellevue, Québec, Canada.
Jozef VercruysseDepartment of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Lindsay H AllenUSDA, ARS Western Human Nutrition Research Center, University of California, Davis, California, United States of America.
Brittany BlouinDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.
Hugo RazuriDivision of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Lidsky PezoAsociación Civil Selva Amazónica, Iquitos, Peru.
Theresa W GyorkosDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.
McGill University · CAAsociación para la Conservación de la Cuenca Amazónica · PEMcGill University Health Centre · CAUniversidad Particular de Iquitos · PEGhent University · BEUniversité de Sherbrooke · CAWestern Human Nutrition Research Center · USWorld Health Organization · CH

Funding

Soil-Transmitted Helminthiases (STH) and DewormingP50AI098574 · NIAID · CIVIL ASSOCIATION OF THE AMAZON JUNGLE · PI CASAPIA, WILFREDO MARTIN · 2012 to 2016
$1.5M
CIHRNIAID NIH HHS P50 AI098574World Health Organization 001
6 · The paper itself

Abstract

backgroundNutritional interventions targeting the critical growth and development period before two years of age can have the greatest impact on health trajectories over the life course. Compelling evidence has demonstrated that interventions investing in maternal health in the first 1000 days of life are beneficial for both mothers and their children. One such potential intervention is deworming integrated into maternal postpartum care in areas where soil-transmitted helminth (STH) infections are endemic. METHODOLOGY/PRINCIPAL

findingsFrom February to August 2014, 1010 mother-infant pairs were recruited into a trial aimed at assessing the effectiveness of maternal postpartum deworming on infant and maternal health outcomes. Following delivery, mothers were randomly assigned to receive either single-dose 400 mg albendazole or placebo. Participants were followed-up at 1 and 6 months postpartum. There was no statistically significant difference in mean weight gain between infants in the experimental and control groups (mean difference: -0.02; 95% CI: -0.1, 0.08) at 6 months of age. Further, deworming had no effect on measured infant morbidity indicators. However, ad hoc analyses restricted to mothers who tested positive for STHs at baseline suggest that infants of mothers in the experimental group had greater mean length gain in cm (mean difference: 0.8; 95% CI: 0.1, 1.4) and length-for-age z-score (mean difference: 0.5; 95% CI: 0.2, 0.8) at 6 months of age. CONCLUSIONS/SIGNIFICANCE: In a study population composed of both STH-infected and uninfected mothers, maternal postpartum deworming was insufficient to impact infant growth and morbidity indicators up to 6 months postpartum. Among STH-infected mothers, however, important improvements in infant length gain and length-for-age were observed. The benefits of maternal postpartum deworming should be further investigated in study populations having higher overall prevalences and intensities of STH infections and, in particular, where whipworm and hookworm infections are of public health concern.

trial registrationClinicalTrials.gov (NCT01748929).

Indexed as

AdultAlbendazoleAnthelminticsDouble-Blind MethodFemaleFollow-Up StudiesHelminthiasisHumansInfantInfant, NewbornInfant, Newborn, DiseasesMaleMothersPeruPostpartum PeriodWeight GainAlbendazoleAnthelmintics

Identifiers

PMID28056024
PMCPMC5215771
OpenAlexW2567744810

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.