ArticleJournal of biomedical optics2017
Optical coherence elastography for evaluating customized riboflavin/UV-A corneal collagen crosslinking.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Ultraviolet Sensing-Guided Biomedical Systems: From Label-Free Imaging to Dosimetry and Therapy Feedback.Biosensors · 2026Review
- Reconstruction of tensile and shear elastic moduli in anisotropic nearly incompressible media using Rayleigh wave phase and group velocities.Journal of biomedical optics · 2025Article
- Assessing UVA and Laser-Induced Crosslinking via Brillouin Microscopy.Journal of biophotonics · 2025Article
- In Vivo Evaluation of the Effects of SMILE with Different Amounts of Stromal Ablation on Corneal Biomechanics by Optical Coherence Elastography.Diagnostics (Basel, Switzerland) · 2022Article
- Micron-scale hysteresis measurement using dynamic optical coherence elastography.Biomedical optics express · 2022Article
- Introduction to optical coherence elastography: tutorial.Journal of the Optical Society of America. A, Optics, image science, and vision · 2022Article
- Assessing corneal cross-linking with reverberant 3D optical coherence elastography.Journal of biomedical optics · 2022Article
- Spatial Assessment of Heterogeneous Tissue Natural Frequency Using Micro-Force Optical Coherence Elastography.Frontiers in bioengineering and biotechnology · 2022Article
- Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022Article
- In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: Repeatability and reproducibility.Journal of biomechanics · 2021Article
- Ultrasound Shear Wave Elastography and Transient Optical Coherence Elastography: Side-by-Side Comparison of Repeatability and Accuracy.IEEE open journal of engineering in medicine and biology · 2021Article
- A review of corneal biomechanics: Mechanisms for measurement and the implications for refractive surgery.Indian journal of ophthalmology · 2020Review
- Dynamic Optical Coherence Elastography of the Anterior Eye: Understanding the Biomechanics of the Limbus.Investigative ophthalmology & visual science · 2020Article
- Characterization of natural frequencies from nanoscale tissue oscillations using dynamic optical coherence elastography.Biomedical optics express · 2020Article
- Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration.Translational vision science & technology · 2020Article
- Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography.Journal of cataract and refractive surgery · 2018Article
- Biomechanical assessment of myocardial infarction using optical coherence elastography.Biomedical optics express · 2018Article
- Optical coherence elastography in ophthalmology.Journal of biomedical optics · 2017Review
- Common-path phase-sensitive optical coherence tomography provides enhanced phase stability and detection sensitivity for dynamic elastography.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
UV-induced collagen cross-linking is a promising treatment for keratoconus that stiffens corneal tissue and prevents further degeneration. Since keratoconus is generally localized, the efficacy of collagen cross-linking (CXL) treatments could be improved by stiffening only the weakened parts of the cornea. Here, we demonstrate that optical coherence elastography (OCE) can spatially resolve transverse variations in corneal stiffness. A short duration ( ? 1 ?? ms ) focused air-pulse induced low amplitude ( ? 10 ?? ? m ) deformations in the samples that were detected using a phase-stabilized optical coherence tomography system. A two-dimensional map of material stiffness was generated by measuring the damped natural frequency (DNF) of the air-pulse induced response at various transverse locations of a heterogeneous phantom mimicking a customized CXL treatment. After validation on the phantoms, similar OCE measurements were made on spatially selective CXL-treated in situ rabbit corneas. The results showed that this technique was able to clearly distinguish the untreated and CXL-treated regions of the cornea, where CXL increased the DNF of the cornea by ? 51 % . Due to the noncontact nature and minimal excitation force, this technique may be valuable for in vivo assessments of corneal biomechanical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.