ArticleNature protocols2017
Preparation and implementation of optofluidic neural probes for in vivo wireless pharmacology and optogenetics.
Article in Nature protocols, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
- IoT-enabled wireless neural implant for chronic, programmable neuropharmacology and optogenetics.Science advances · 2026Article
- 3D-printed optogenetic neural probe integrated with microfluidic tube for opsin/drug delivery.Scientific reports · 2025Article
- Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems.Bioactive materials · 2025Review
- Wireless Modular Implantable Neural Device with One-touch Magnetic Assembly for Versatile Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ex vivo liquid core fiber photometry with high-resolution 3D printing.Sensors and actuators reports · 2024Article
- Multifunctional microelectronic fibers enable wireless modulation of gut and brain neural circuits.Nature biotechnology · 2024Article
- A wireless, solar-powered, optoelectronic system for spatial restriction-free long-term optogenetic neuromodulations.Science advances · 2023Article
- Self-assembled ultraflexible probes for long-term neural recordings and neuromodulation.Nature protocols · 2023Review
- Wireless and battery-free technologies for neuroengineering.Nature biomedical engineering · 2023Review
- Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices.BME frontiers · 2023Review
- Customizable, wireless and implantable neural probe design and fabrication via 3D printing.Nature protocols · 2023Review
- Emerging Optoelectronic Devices Based on Microscale LEDs and Their Use as Implantable Biomedical Applications.Micromachines · 2022Review
- Porosity-based heterojunctions enable leadless optoelectronic modulation of tissues.Nature materials · 2022Article
- Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience.Nature biomedical engineering · 2022Article
- Review
- Review
- Optical Fibre-Enabled Photoswitching for Localised Activation of an Anti-Cancer Therapeutic Drug.International journal of molecular sciences · 2021Article
- Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics.Nature communications · 2021Article
- 3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics.Nature communications · 2021Article
- A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery.Microsystems & nanoengineering · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
This Protocol Extension describes the fabrication and technical procedures for implementing ultrathin, flexible optofluidic neural probe systems that provide targeted, wireless delivery of fluids and light into the brains of awake, freely behaving animals. As a Protocol Extension article, this article describes an adaptation of an existing Protocol that offers additional applications. This protocol serves as an extension of an existing Nature Protocol describing optoelectronic devices for studying intact neural systems. Here, we describe additional features of fabricating self-contained platforms that involve flexible microfluidic probes, pumping systems, microscale inorganic LEDs, wireless-control electronics, and power supplies. These small, flexible probes minimize tissue damage and inflammation, making long-term implantation possible. The capabilities include wireless pharmacological and optical intervention for dissecting neural circuitry during behavior. The fabrication can be completed in 1-2 weeks, and the devices can be used for 1-2 weeks of in vivo rodent experiments. To successfully carry out the protocol, researchers should have basic skill sets in photolithography and soft lithography, as well as experience with stereotaxic surgery and behavioral neuroscience practices. These fabrication processes and implementation protocols will increase access to wireless optofluidic neural probes for advanced in vivo pharmacology and optogenetics in freely moving rodents.This protocol is an extension to: Nat. Protoc. 8, 2413-2428 (2013); doi:10.1038/nprot.2013.158; published online 07 November 2013.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.