Evidence map›Paper›PMID 28054995›Full record

ArticleMolecules (Basel, Switzerland)2017

Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites.

Tamila Galaka, Mariana Ferrer Casal, Melissa Storey, Catherine Li, María N Chao, Sergio H Szajnman, Roberto Docampo, Silvia N J Moreno, Juan B Rodriguez

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Synthesis of Amino-Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tamila GalakaDepartamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina. galakatamila@qo.fcen.uba.ar.
Mariana Ferrer CasalDepartamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina. mferrer@qo.fcen.uba.ar.
Melissa StoreyCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. mtayl04@uga.edu.
Catherine LiCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. catli@uga.edu.
María N ChaoDepartamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina. nchao@qo.fcen.uba.ar.
Sergio H SzajnmanDepartamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina. shs@qo.fcen.uba.ar.
Roberto DocampoCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. rdocampo@uga.edu.
Silvia N J MorenoCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. smoreno@uga.edu.
Juan B RodriguezDepartamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina. jbr@qo.fcen.uba.ar.

Funding

Pathogenesis of Trypanosoma cruzi infectionR01AI107663 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2014 to 2017
$1.5M
Targeting Host and Apicomplexan Isoprenoid PathwaysR33AI102254 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2014 to 2016
$1.3M
Targeting Host and Apicomplexan Isoprenoid PathwaysR21AI102254 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2012 to 2013
$408k
Pathogenesis of Trypanosoma cruzi infectionR56AI107663 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2013 to 2013
$350k
NIAID NIH HHS R01 AI107663NIAID NIH HHS R21 AI102254NIAID NIH HHS R33 AI102254NIAID NIH HHS R56 AI107663
6 · The paper itself

Abstract

Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates-

Indexed as

AnimalsAntiprotozoal AgentsChlorocebus aethiopsDiphosphonatesEnzyme AssaysEnzyme InhibitorsGene ExpressionGeranyltranstransferaseHalogenationHumansParasitic Sensitivity TestsProtozoan ProteinsStructure-Activity RelationshipToxoplasmaTrypanosoma cruziVero CellsAntiprotozoal AgentsDiphosphonatesEnzyme InhibitorsGeranyltranstransferaseProtozoan Proteinsantiparasitic agentsbisphosphonatesChagas diseasefarnesyl diphosphate synthaseToxoplasma gondiitoxoplasmosisTrypanosoma cruzi

Identifiers

PMID28054995
PMCPMC6155738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.