ArticleAntiviral therapy2017
Association of HIV infection with biomarkers of kidney injury and fibrosis in the Multicenter AIDS Cohort Study.
Article in Antiviral therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Associations of repeated measures of plasma biomarkers of kidney tubular health with longitudinal kidney function in people with HIV.AIDS (London, England) · 2026Article
- Kidney disease among adults on tenofovir-based second-line antiretroviral therapy in Dar es Salaam, Tanzania.Southern African journal of HIV medicine · 2025Article
- Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia.Frontiers in nephrology · 2024Article
- Soluble Insulin Receptor Levels in Plasma, Exosomes, and Urine and Its Association With HIV-Associated Neurocognitive Disorders.Frontiers in neurology · 2022Article
- Urinary biomarkers of early renal injury in antiretroviral-naïve HIV-positive persons in Shanghai, China: comparison with the general population.HIV medicine · 2021Article
- Associations of CKD risk factors and longitudinal changes in urine biomarkers of kidney tubules among women living with HIV.BMC nephrology · 2021Article
- Kidney tubule health scores and their associations with incident CKD in women living with HIV.HIV medicine · 2021Article
- Observational
- The utility of kidney injury molecule-1 as an early biomarker of kidney injury in people living with HIV.International journal of STD & AIDS · 2020Article
- HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: role of platelet-derived TGF-β1 and intervention via antioxidant pathways.AIDS (London, England) · 2020Article
- Association of Statin Use With Kidney Damage and Function Among HIV-Infected Men.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Biomarkers of Acute and Chronic Kidney Disease.Annual review of physiology · 2019Review
- Associations of Urine Biomarkers with Kidney Function Decline in HIV-Infected and Uninfected Men.American journal of nephrology · 2019Article
- Long-term kidney function, proteinuria, and associated risks among HIV-infected and uninfected men.AIDS (London, England) · 2018Article
- Urine Biomarkers of Kidney Tubule Health and Incident CKD Stage 3 in Women Living With HIV: A Repeated Measures Study.Kidney medicineArticle
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Authors and funding
11 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundChronic kidney disease (CKD) is common among HIV-infected individuals but serum creatinine is insensitive for detecting kidney damage at early stages. We hypothesized that HIV infection would be associated with elevations in subclinical markers of kidney injury and fibrosis in a contemporary cohort of men.
methodsIn this cross-sectional study, we measured urine levels of interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), pro-collagen type III N-terminal pro-peptide (PIIINP) and albumin-creatinine ratio (ACR) in 813 HIV-infected and 331 uninfected men enrolled in the Multicenter AIDS Cohort Study.
resultsMedian eGFR was 95 ml/min/1.73 m
conclusionsCompared with uninfected men, HIV-infected men had more extensive glomerular and tubulointerstitial damage, as assessed by urine biomarkers. Future studies should evaluate whether combinations of biomarkers can be used to monitor stages of kidney injury and to predict CKD risk in HIV-infected individuals.
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