Evidence map›Paper›PMID 28054827›Full record

ReviewAmyotrophic lateral sclerosis & frontotemporal degeneration2017

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria.

Michael J Strong, Sharon Abrahams, Laura H Goldstein, Susan Woolley, Paula Mclaughlin, Julie Snowden, Eneida Mioshi, Angie Roberts-South, Michael Benatar, Tibor HortobáGyi and 4 more

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06566651 (Emotion and Interoception Processing in ALS), which is not on this map. Cited by 504 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
504citing papers in PubMed, 8 pooled it
45.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06566651 recruitingnot on this mapstarted 2023, after this paper: background citation

Emotion and Interoception Processing in ALS

TypeobservationalSponsorUniversity of AarhusRan2023 to 2026Enrolled180ConditionsAmyotrophic Lateral Sclerosis, Neuromuscular Diseases, ALS, Motor Neuron DiseaseArmsEmotion Discrimination Task (EDT)
3 · Its place in the literature

Who cites it

504 citing papers in PubMed, 8 syntheses or guidelines pooled it, 882 citations in OpenAlex.

  1. Pooled it
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  6. Quality of life, cognitive and behavioural impairment in people with motor neuron disease: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Pooled it
  7. Guideline
  8. Pooled it
  9. Trial
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  11. Review
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  19. Methodological insights and clinical outcomes in ALS and FTLD: lessons from the SPIN cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  20. Article

444 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 5 countries.

Michael J Stronga Department of Clinical Neurological Sciences, Schulich School of Medicine & Dentistry , London , Ontario , Canada.
Sharon Abrahamsb Department of Psychology, School of Philosophy, Psychology & Language Sciences , Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh , Edinburgh , UK.
Laura H Goldsteinc King's College London, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience , London , UK.
Susan Woolleyd Forbes Norris MDA/ALS Research Centre, California Pacific Medical Centre , San Francisco , CA , USA.
Paula Mclaughline Western University , Schulich School of Medicine & Dentistry , London , ON , Canada.
Julie Snowdenf Greater Manchester Neuroscience Centre , Salford Royal NHS Trust and University of Manchester , Manchester , UK.
Eneida Mioshig Faculty of Medicine and Health Sciences , University of East Anglia , Norwich , UK.
Angie Roberts-Southh Northwestern University , Roxelyn and Richard Pepper Department of Communication Sciences and Disorders , Evanston , IL , USA.
Michael Benatari Department of Neurology , University of Miami Miller School of Medicine , Miami , FL , USA.
Tibor HortobáGyij Department of Neuropathology , Institute of Pathology, University of Debrecen , Debrecen , Hungary.
Jeffrey Rosenfeldk Department of Neurology , Loma Linda University School of Medicine , Loma Linda , CA , USA.
Vincenzo Silanil Department of Neurology and Laboratory Neuroscience - IRCCS Istituto Auxologico Italiano, Department of Pathophysiology and Transplantation , 'Dino Ferrari' Centre, Università degli Studi di Milano , Milan , Italy.
Paul G Incem Sheffield Institute for Translational Neuroscience, Department of Neuroscience , The University of Sheffield , Sheffield , UK , and.
Martin R Turnern Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.
Western University · CACalifornia Pacific Medical Center · USKing's College London · GBLoma Linda University · USNorthwestern University · USUniversity of Debrecen · HUUniversity of East Anglia · GBUniversity of Edinburgh · GBUniversity of Manchester · GBUniversity of Miami · USUniversity of Milan · ITUniversity of Oxford · GBUniversity of Sheffield · GB

Funding

Uncovering new genes and disease modifiers for ALS and related disordersU54NS092091 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Michael Benatar · 2014 to 2026
$19.8M
Medical Research Council MR/K01014X/1Medical Research Council MR/K026992/1Motor Neurone Disease Association TURNER/JAN13/944-795NINDS NIH HHS U54 NS092091
6 · The paper itself

Abstract

This article presents the revised consensus criteria for the diagnosis of frontotemporal dysfunction in amyotrophic lateral sclerosis (ALS) based on an international research workshop on frontotemporal dementia (FTD) and ALS held in London, Canada in June 2015. Since the publication of the Strong criteria, there have been considerable advances in the understanding of the neuropsychological profile of patients with ALS. Not only is the breadth and depth of neuropsychological findings broader than previously recognised - - including deficits in social cognition and language - but mixed deficits may also occur. Evidence now shows that the neuropsychological deficits in ALS are extremely heterogeneous, affecting over 50% of persons with ALS. When present, these deficits significantly and adversely impact patient survival. It is the recognition of this clinical heterogeneity in association with neuroimaging, genetic and neuropathological advances that has led to the current re-conceptualisation that neuropsychological deficits in ALS fall along a spectrum. These revised consensus criteria expand upon those of 2009 and embrace the concept of the frontotemporal spectrum disorder of ALS (ALS-FTSD).

Indexed as

Amyotrophic Lateral SclerosisCanadaDiagnosis, DifferentialFrontotemporal DementiaHumansLanguageNeuroimagingNeuropsychological TestsSocial PerceptionSurvival AnalysisAmyotrophic lateral sclerosisbehaviourcognitionfrontotemporal dementiageneticsneuropsychology

Identifiers

PMID28054827
PMCPMC7409990
OpenAlexW2562172900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.