ArticleScientific reports2017
Yersinia pestis halotolerance illuminates plague reservoirs.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Environmental and Host Blood Interactions ShapePathogens (Basel, Switzerland) · 2026Article
- Evolutionary trends of plague research from 2016 to 2025: A bibliometric analysis.PLoS neglected tropical diseases · 2026Article
- Emergence, global dispersal, and local adaptations ofApplied and environmental microbiology · 2026Review
- Interaction of Bacteria and Fleas, Focusing on the Plague Bacterium-A Review.Microorganisms · 2025Review
- The interplay between species and locations shapes vector fleas microbial communities in plague foci: pathogens rather than symbionts?Frontiers in cellular and infection microbiology · 2025Article
- Molecular detection and characterization ofInfection ecology & epidemiology · 2025Article
- Development of a cost-effective LAMP method for screening and monitoring enteropathogenicScience in One Health · 2025Article
- The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights.Microorganisms · 2024Review
- Different characteristics of the soil in marmot habitats might be one of the factors that influctingFrontiers in microbiology · 2024Article
- The reproduction of gram-negative protoplasts and the influence of environmental conditions on this process.iScience · 2023Article
- Article
- No evidence for persistent natural plague reservoirs in historical and modern Europe.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Plague risk in the western United States over seven decades of environmental change.Global change biology · 2022Article
- Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020Review
- Soil salinity and aridity specify plague foci in the United States of America.Scientific reports · 2020Article
- Ancient pathogen genomics as an emerging tool for infectious disease research.Nature reviews. Genetics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plague agent Yersinia pestis persists for years in the soil. Two millennia after swiping over Europe and North Africa, plague established permanent foci in North Africa but not in neighboring Europe. Mapping human plague foci reported in North Africa for 70 years indicated a significant location at <3 kilometers from the Mediterranean seashore or the edge of salted lakes named chotts. In Algeria, culturing 352 environmental specimens naturally containing 0.5 to 70 g/L NaCl yielded one Y. pestis Orientalis biotype isolate in a 40 g/L NaCl chott soil specimen. Core genome SNP analysis placed this isolate within the Y. pestis branch 1, Orientalis biovar. Culturing Y. pestis in broth steadily enriched in NaCl indicated survival up to 150 g/L NaCl as L-form variants exhibiting a distinctive matrix assisted laser desorption-ionization time-of-flight mass spectrometry peptide profile. Further transcriptomic analyses found the upregulation of several outer-membrane proteins including TolC efflux pump and OmpF porin implied in osmotic pressure regulation. Salt tolerance of Y. pestis L-form may play a role in the maintenance of natural plague foci in North Africa and beyond, as these geographical correlations could be extended to 31 plague foci in the northern hemisphere (from 15°N to 50°N).
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