ArticleScientific reports2017
Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Physiological limits of capillary refill time: a human endotoxemia study.Critical care (London, England) · 2026Trial
- In vivo Cytokine Adsorption Reveals Distinct Neutrophil Mobilization Pathways during Experimental Human Endotoxemia.Journal of innate immunity · 2026Trial
- Inflammatory endotoxin challenge in individuals with alcohol use disorder and controls.Alcohol, clinical & experimental research · 2025Trial
- Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.Critical care medicine · 2019Trial
- Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.British journal of clinical pharmacology · 2018Trial
- Sepsis modelling: current approaches and organ-on-chip perspectives.EBioMedicine · 2026Review
- Inflammatory models of depression in rodents and humans.Frontiers in psychiatry · 2026Review
- Embracing the complexity of alcohol's immunomodulatory effects: Commentary on Monnig, Lamb, Clark, and Monti-"Acute changes in immune biomarkers under low and moderate dose alcohol in light and heavy drinkers: A randomized, placebo-controlled trial".Alcohol, clinical & experimental research · 2025Article
- Acute inflammation induced by the Escherichia coli lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice.The international journal of neuropsychopharmacology · 2025Article
- Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia.Frontiers in immunology · 2025Article
- Mathematical model of the inflammatory response to acute and prolonged lipopolysaccharide exposure in humans.NPJ systems biology and applications · 2024Article
- Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modelling.Experimental physiology · 2024Article
- Article
- Altered response to Toll-like receptor 4 activation in fibromyalgia: A low-dose, human experimental endotoxemia pilot study.Brain, behavior, & immunity - health · 2023Article
- Processing stimulus dynamics by the NF-κB network in single cells.Experimental & molecular medicine · 2023Review
- NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli.Cell reports · 2022Article
- Effects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Mice.Healthcare (Basel, Switzerland) · 2022Article
- Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge.Alcohol and alcoholism (Oxford, Oxfordshire) · 2021Article
- Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression.Molecular psychiatry · 2021Review
- Biomarker-Guided Individualization of Antibiotic Therapy.Clinical pharmacology and therapeutics · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigating the systemic inflammatory response in patients with critical illness such as sepsis, trauma and burns is complicated due to uncertainties about the onset, duration and severity of the insult. Therefore, in vivo models of inflammation are essential to study the pathophysiology and to evaluate immunomodulatory therapies. Intravenous bolus administration of endotoxin to healthy volunteers is a well-established model of a short-lived systemic inflammatory response, characterized by increased plasma cytokine levels, flu-like symptoms and fever. In contrast, patients suffering from systemic inflammation are often exposed to inflammatory stimuli for an extended period of time. Therefore, continuous infusion of endotoxin may better reflect the kinetics of the inflammatory response encountered in these patients. Herein, we characterize a novel model of systemic inflammation elicited by a bolus infusion of 1 ng/kg, followed by a 3hr continuous infusion of 1 ng/kg/h of endotoxin in healthy volunteers, and compared it with models of bolus administrations of 1 and 2 ng/kg of endotoxin. The novel model was well-tolerated and resulted in a more pronounced increase in plasma cytokine levels with different kinetics and more prolonged symptoms and fever compared with the bolus-only models. Therefore, the continuous endotoxin infusion model provides novel insights into kinetics of the inflammatory response during continuous inflammatory stimuli and accommodates a larger time window to evaluate immunomodulating therapies.
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