SynthesisScientific reports2017
The effectiveness of pressure therapy (15-25 mmHg) for hypertrophic burn scars: A systematic review and meta-analysis.
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pressure-garment therapy for preventing hypertrophic scarring after burn injury.The Cochrane database of systematic reviews · 2024Pooled it
- Efficacy and Safety of Pressure Therapy Alone and in Combination with Silicone in Prevention of Hypertrophic Scars: A Systematic Review with Meta-analysis of Randomized Controlled Trials.Aesthetic plastic surgery · 2023Pooled it
- Mesenchymal stem cell therapy in hypertrophic and keloid scars.Cell and tissue research · 2021Pooled it
- Efficacy of topical silicone gel in scar management: A systematic review and meta-analysis of randomised controlled trials.International wound journal · 2020Pooled it
- Within-Patient, Evaluator-Blinded, Randomized Controlled Clinical Trial to Assess the Efficacy of Gel Sheets in the Treatment of Hypertrophic Scar in Adult Burn Survivors.Journal of burn care & research : official publication of the American Burn Association · 2026Trial
- Cost-effectiveness of scar management post-burn: a trial-based economic evaluation of three intervention models.Scientific reports · 2022Trial
- [A prospective randomized controlled study of the effects of balance training combined with routine training on patients with lower limb motor and balance dysfunction after severe burns].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Trial
- Effectiveness of topical silicone gel and pressure garment therapy for burn scar prevention and management in children: a randomized controlled trial.Clinical rehabilitation · 2020Trial
- Personalized Clinical Workflow for Compression Therapy in Post-Burn Hypertrophic Scars Using 3D Imaging and Computational Modeling: A Feasibility Study.Healthcare (Basel, Switzerland) · 2026Article
- Recent advances on anti-scarring properties of amniotic membrane: emerging strategies and clinical potentials in regenerative medicine.Stem cell research & therapy · 2026Review
- Low-fatigue, adjustable pressure garments at 10, 20 and 30 mm Hg reduce scar thickness and improve pliability.PloS one · 2026Article
- Comprehensive Update on Keloid Management.Archives of plastic surgery · 2026Article
- Post-surgical scar management and rehabilitation in burn patients: Insights from Gaza's challenging context - A retrospective descriptive study.PLOS global public health · 2026Article
- Effects of compression therapy on the upper limb of patients with stroke: a systematic review protocol.BMJ open · 2025Article
- Evidence Supporting Conservative Scar Management Interventions Following Burn Injury: A Review Article.Journal of burn care & research : official publication of the American Burn Association · 2025Review
- Review
- The Validation of the 'CARe Burn Scale: Parent/Caregiver Form'-A Patient Reported Outcome Measure (PROM) Using Rasch Measurement Theory (RMT) to Assess Quality of Life for Parents or Caregivers Supporting a Child with a Burn Injury.European burn journal · 2025Article
- Scar Management in Pediatric Patients.Medicina (Kaunas, Lithuania) · 2025Review
- Preliminary Study on the Development of a Real-Time Pressure-Monitoring Facial Mask for Burn Rehabilitation.European burn journal · 2025Article
- Tension-sensitive HOX gene expression in fibroblasts for differential scar formation.Journal of translational medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although pressure therapy (PT) represents the standard care for prevention and treatment of hypertrophic scar (HS) from burns, its practice is largely based on empirical evidence and its effectiveness remains controversial. To clarify the effect of PT (15-25 mmHg) for HS, we performed the systematic review and meta-analysis. Several electronic databases were screened to identify related randomized controlled trials (RCTs). 12 RCTs involving 710 patients with 761 HS resulting from burn injuries were included. Compared with non/low-PT, cases treated with PT (15-25 mmHg) showed significant differences in Vancouver Scar Scale score (MD = -0.58, 95% CI = -0.78--0.37), thickness (SMD = -0.25, 95% CI = -0.40--0.11), brightness (MD = 2.00, 95% CI = 0.59-3.42), redness (MD = -0.79, 95% CI = -1.52--0.07), pigmentation (MD = -0.16, 95% CI = -0.32--0.00) and hardness (SMD = -0.65, 95% CI = -1.07--0.23). However, there was no difference in vascularity (MD = 0.03, 95% CI = -0.43-0.48). Our analysis indicated that patients with HS who were managed with PT (15-25 mmHg) showed significant improvements. Due to limitations, more large and well-designed studies are needed to confirm our findings and the side-effects of the PT may also need to be evaluated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.