ArticleScientific reports2017
Atomic scale chemical tomography of human bone.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Scaffold Design: A Review of Material and Immune Modulation in Bone Tissue Engineering.Cell and tissue banking · 2026Review
- Bone hierarchical organization through the lens of materials science: Present opportunities and future challenges.Bone reports · 2024Review
- Resolving protein-mineral interfacial interactions duringMaterials today. Advances · 2023Article
- Nanoscale analysis of frozen honey by atom probe tomography.Scientific reports · 2022Article
- Age-related changes in cationic compositions of human cranial base bone apatite measured by X-ray energy dispersive spectroscopy (EDS) coupled with scanning electron microscope (SEM).Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Matrix/mineral ratio and domain size variation with bone tissue age: A photothermal infrared study.Journal of structural biology · 2022Article
- Mapping cortical bone stiffness and mineralization from endosteal to periosteal surfaces of bovine mid-diaphyseal femur.Journal of bone and mineral metabolism · 2021Article
- The homogenous alternative to biomineralization: Zn- and Mn-rich materials enable sharp organismal "tools" that reduce force requirements.Scientific reports · 2021Article
- DNA nanostructures as templates for biomineralization.Nature reviews. Chemistry · 2021Review
- Atom probe tomography.Nature reviews. Methods primers · 2021Article
- Field evaporation and atom probe tomography of pure water tips.Scientific reports · 2020Article
- New frontiers in atom probe tomography: a review of research enabled by cryo and/or vacuum transfer systems.Materials today. Advances · 2020Article
- Chemical gradients in human enamel crystallites.Nature · 2020Article
- A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography.Scientific reports · 2018Article
- A multiscale analytical approach to evaluate osseointegration.Journal of materials science. Materials in medicine · 2018Review
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Authors and funding
3 authors.
Funding
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Abstract
Human bone is a complex hierarchical material. Understanding bone structure and its corresponding composition at the nanometer scale is critical for elucidating mechanisms of biomineralization under healthy and pathological states. However, the three-dimensional structure and chemical nature of bone remains largely unexplored at the nanometer scale due to the challenges associated with characterizing both the structural and chemical integrity of bone simultaneously. Here, we use correlative transmission electron microscopy and atom probe tomography for the first time, to our knowledge, to reveal structures in human bone at the atomic level. This approach provides an overlaying chemical map of the organic and inorganic constituents of bone on its structure. This first use of atom probe tomography on human bone reveals local gradients, trace element detection of Mg, and the co-localization of Na with the inorganic-organic interface of bone mineral and collagen fibrils, suggesting the important role of Na-rich organics in the structural connection between mineral and collagen. Our findings provide the first insights into the hierarchical organization and chemical heterogeneity in human bone in three-dimensions at its smallest length scale - the atomic level. We demonstrate that atom probe tomography shows potential for new insights in biomineralization research on bone.
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