ArticleScientific reports2017
Kilohertz frequency nerve block enhances anti-inflammatory effects of vagus nerve stimulation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Influence of Sacral and Thoracolumbar Spinal Nerve Electrical Stimulation on Colonic Motility in Anesthetized Yucatan Male Pigs.Neurogastroenterology and motility · 2026Article
- Ramped kilohertz-frequency signals produce nerve conduction block without onset response.Journal of neural engineering · 2025Article
- Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity.Frontiers in immunology · 2025Review
- Using neural biomarkers to personalize dosing of vagus nerve stimulation.Bioelectronic medicine · 2024Article
- Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives.Frontiers in neuroscience · 2024Review
- Stimulation parameters for directional vagus nerve stimulation.Bioelectronic medicine · 2023Article
- Bioelectronic medicine for restoring autonomic balance in autoimmune diseases.Gut microbiota and integrative wellness · 2023Article
- Effects of waveform shape and electrode material on KiloHertz frequency alternating current block of mammalian peripheral nerve.Bioelectronic medicine · 2022Article
- Blood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model.Physiological reports · 2022Article
- Scalable and reversible axonal neuromodulation of the sympathetic chain for cardiac control.American journal of physiology. Heart and circulatory physiology · 2022Article
- Human-relevant near-organ neuromodulation of the immune system via the splenic nerve.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Divergence of neuroimmune circuits activated by afferent and efferent vagal nerve stimulation in the regulation of inflammation.The Journal of physiology · 2021Article
- Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver.Journal of immunology research · 2021Article
- Selective Neuromodulation of the Vagus Nerve.Frontiers in neuroscience · 2021Review
- Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease.Frontiers in neuroscience · 2021Review
- Designing a bioelectronic treatment for Type 1 diabetes: targeted parasympathetic modulation of insulin secretion.Bioelectronics in medicine · 2020Review
- Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions.Physiological reports · 2020Article
- Counted cycles method to measure the block inception time of kiloHertz frequency mammalian motor nerve block.Journal of neuroscience methods · 2020Article
- Quantified Morphology of the Cervical and Subdiaphragmatic Vagus Nerves of Human, Pig, and Rat.Frontiers in neuroscience · 2020Article
- Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig.Scientific reports · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Efferent activation of the cervical vagus nerve (cVN) dampens systemic inflammatory processes, potentially modulating a wide-range of inflammatory pathological conditions. In contrast, afferent cVN activation amplifies systemic inflammatory processes, leading to activation of the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system through the greater splanchnic nerve (GSN), and elevation of pro-inflammatory cytokines. Ideally, to clinically implement anti-inflammatory therapy via cervical vagus nerve stimulation (cVNS) one should selectively activate the efferent pathway. Unfortunately, current implementations, in animal and clinical investigations, activate both afferent and efferent pathways. We paired cVNS with kilohertz electrical stimulation (KES) nerve block to preferentially activate efferent pathways while blocking afferent pathways. Selective efferent cVNS enhanced the anti-inflammatory effects of cVNS. Our results demonstrate that: (i) afferent, but not efferent, cVNS synchronously activates the GSN in a dose-dependent manner; (ii) efferent cVNS enabled by complete afferent KES nerve block enhances the anti-inflammatory benefits of cVNS; and (iii) incomplete afferent KES nerve block exacerbates systemic inflammation. Overall, these data demonstrate the utility of paired efferent cVNS and afferent KES nerve block for achieving selective efferent cVNS, specifically as it relates to neuromodulation of systemic inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.