Evidence map›Paper›PMID 28054487›Full record

ArticleJournal of the American Chemical Society2017

Guanidinium can both Cause and Prevent the Hydrophobic Collapse of Biomacromolecules.

Jan Heyda, Halil I Okur, Jana Hladílková, Kelvin B Rembert, William Hunn, Tinglu Yang, Joachim Dzubiella, Pavel Jungwirth, Paul S Cremer

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 95 citations in OpenAlex.

  1. ACS applied polymer materials · 2026
    Article
  2. Article
  3. Article
  4. ATP Can Act as a Stabilizer on Neutral Macromolecules.The journal of physical chemistry letters · 2025
    Article
  5. Article
  6. Article
  7. Greasy Cations Bind to Neutral Macromolecules in Aqueous Solution.The journal of physical chemistry letters · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Anion-specific structure and stability of guanidinium-bound DNA origami.Computational and structural biotechnology journal · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Jan HeydaInstitut für Weiche Materie und Funktionale Materialien, Helmholtz-Zentrum Berlin für Materialien und Energie , Hahn-Meitner Platz 1, 14109 Berlin, Germany.
Halil I Okur
Jana HladílkováDivision of Theoretical Chemistry, Lund University , POB 124, 22 100 Lund, Sweden.
Kelvin B Rembert
William HunnChemistry Department, Texas A&M University , 3255 TAMU, College Station, Texas 77843, United States.
Tinglu Yang
Joachim DzubiellaInstitut für Weiche Materie und Funktionale Materialien, Helmholtz-Zentrum Berlin für Materialien und Energie , Hahn-Meitner Platz 1, 14109 Berlin, Germany.ORCID 0000-0001-6751-1487
Pavel JungwirthInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Flemingovo nám. 2, 16610 Prague 6, Czech Republic.
Helmholtz-Zentrum Berlin für Materialien und Energie · DECzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZLund University · SETexas A&M University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A combination of Fourier transform infrared and phase transition measurements as well as molecular computer simulations, and thermodynamic modeling were performed to probe the mechanisms by which guanidinium (Gnd

Indexed as

CationsGuanidineHydrophobic and Hydrophilic InteractionsPeptidesSpectroscopy, Fourier Transform InfraredThermodynamicsCationsGuanidinePeptides

Identifiers

PMID28054487
PMCPMC5499822
OpenAlexW2570825876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.