Evidence map›Paper›PMID 28054395›Full record

SynthesisAlcoholism, clinical and experimental research2017

Inhalation of Alcohol Vapor: Measurement and Implications.

Robert Ross MacLean, Gerald W Valentine, Peter I Jatlow, Mehmet Sofuoglu

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Alcoholism, clinical and experimental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
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  3. Proof of Concept: Is Small-scale Production of Diethyl Ether for Anesthetic Use Possible?Journal of special operations medicine : a peer reviewed journal for SOF medical professionals · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robert Ross MacLeanDepartment of Psychiatry, School of Medicine, Yale University, West Haven, Connecticut.ORCID 0000-0001-8067-7828
Gerald W ValentineDepartment of Psychiatry, School of Medicine, Yale University, West Haven, Connecticut.
Peter I JatlowLaboratory Medicine, Yale University, West Haven, Connecticut.
Mehmet SofuogluDepartment of Psychiatry, School of Medicine, Yale University, West Haven, Connecticut.
Yale University · US

Funding

Yale Tobacco Center of Regulatory ScienceP50DA036151 · NIDA · YALE UNIVERSITY · PI KRISHNAN-SARIN, SUCHITRA, O'MALLEY, STEPHANIE S · 2013 to 2017
$20.6M
Cholinergic Enhancement as Treatment for Nicotine AddictionR21DA034815 · NIDA · YALE UNIVERSITY · PI SOFUOGLU, MEHMET, WATERS, ANDREW J · 2013 to 2014
$376k
NIDA NIH HHS P50 DA036151NIDA NIH HHS R21 DA034815
6 · The paper itself

Abstract

Decades of alcohol research have established the health risks and pharmacodynamic profile of oral alcohol consumption. Despite isolated periods of public health concern, comparatively less research has evaluated exposure to alcohol vapor. Inhaled alcohol initially bypasses first-pass metabolism and rapidly reaches the arterial circulation and the brain, suggesting that this route of administration may be associated with pharmacological effects that increase the risk of addiction. However, detailed reviews assessing the possible effects of inhaled alcohol in humans are lacking. A comprehensive, systematic literature review was conducted using Google Scholar and PubMed to examine manuscripts studying exposure to inhaled alcohol and measurement of biomarkers (biochemical or functional) associated with alcohol consumption in human participants. Twenty-one publications reported on alcohol inhalation. Fourteen studies examined inhalation of alcohol vapor associated with occupational exposure (e.g., hand sanitizer) in a variety of settings (e.g., naturalistic, laboratory). Six publications measured inhalation of alcohol in a controlled laboratory chamber, and 1 evaluated direct inhalation of an e-cigarette with ethanol-containing "e-liquid." Some studies have reported that inhalation of alcohol vapor results in measurable biomarkers of acute alcohol exposure, most notably ethyl glucuronide. Despite the lack of significantly elevated blood alcohol concentrations, the behavioral consequences and subjective effects associated with repeated use of devices capable of delivering alcohol vapor are yet to be determined. No studies have focused on vulnerable populations, such as adolescents or individuals with alcohol use disorder, who may be most at risk of problems associated with alcohol inhalation.

Indexed as

Administration, InhalationAdolescentAlcohol DrinkingAnimalsCentral Nervous System DepressantsElectronic Nicotine Delivery SystemsEthanolHumansVapingCentral Nervous System DepressantsEthanolAlcohol InhalationAlcohol Without LiquidEthanol VaporVapingVaportini

Identifiers

PMID28054395
PMCPMC6143144
OpenAlexW2570051374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.