Evidence map›Paper›PMID 28054322›Full record

Trial reportSports medicine (Auckland, N.Z.)2017

Creatine Loading Does Not Preserve Muscle Mass or Strength During Leg Immobilization in Healthy, Young Males: A Randomized Controlled Trial.

Evelien M P Backx, Roland Hangelbroek, Tim Snijders, Marie-Louise Verscheijden, Lex B Verdijk, Lisette C P G M de Groot, Luc J C van Loon

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sports medicine (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01894737 (The Effect of Creatine Supplementation on Muscle Loss During Immobilisation), which is not on this map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01894737 nacompletednot on this map

The Effect of Creatine Supplementation on Muscle Loss During Immobilisation

TypeinterventionalSponsorMaastricht University Medical CenterRan2013 to 2015Enrolled30ConditionsMuscle LossArmsPlacebo supplementation, Creatine supplementation
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  12. Integrated muscle protein synthesis during disuse and rehabilitation in late-midlife adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Evelien M P BackxDepartment of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Roland HangelbroekDepartment of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Tim SnijdersTop Institute Food and Nutrition, Wageningen, The Netherlands.
Marie-Louise VerscheijdenDepartment of Surgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Lex B VerdijkTop Institute Food and Nutrition, Wageningen, The Netherlands.
Lisette C P G M de GrootDepartment of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Luc J C van LoonTop Institute Food and Nutrition, Wageningen, The Netherlands. L.vanLoon@maastrichtuniversity.nl.
TiFN · NLMaastricht University · NLMaastricht University Medical Centre · NLWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA short period of leg immobilization leads to rapid loss of muscle mass and strength. Creatine supplementation has been shown to increase lean body mass in active individuals and can be used to augment gains in muscle mass and strength during prolonged resistance-type exercise training.

objectiveOur objective was to investigate whether creatine loading can attenuate the loss of muscle mass and strength during short-term leg immobilization.

methodsHealthy young men (n = 30; aged 23 ± 1 years; body mass index [BMI] 23.3 ± 0.5 kg/m

resultsThere was a significant overall increase in muscle total creatine content following the 5-day loading phase (p = 0.049), which appeared driven by an increase in the creatine group (from 90 ± 9 to 107 ± 4 mmol/kg

conclusionCreatine supplementation prior to and during leg immobilization does not prevent or attenuate the loss of muscle mass or strength during short-term muscle disuse. NIH Clinical Trial Registration Number: NCT01894737 ( http://www.clinicaltrials.gov/ ).

Indexed as

Dietary SupplementsAdministration, OralBiopsyBody CompositionBody Mass IndexCasts, SurgicalCreatineDouble-Blind MethodHealthy VolunteersHumansImmobilizationMaleMuscle, SkeletalMuscle StrengthResistance TrainingTomography, X-Ray ComputedCreatine

Identifiers

PMID28054322
PMCPMC5507980
OpenAlexW2568037712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.