Evidence map›Paper›PMID 28054308›Full record

ArticleThe journal of physiological sciences : JPS2018

Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist.

Mariko So, Hirofumi Hashimoto, Reiko Saito, Yukiyo Yamamoto, Yasuhito Motojima, Hiromichi Ueno, Satomi Sonoda, Mitsuhiro Yoshimura, Takashi Maruyama, Koichi Kusuhara and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025
    Review
  2. Review
  3. "Sibling" battle or harmony: crosstalk between nesfatin-1 and ghrelin.Cellular and molecular life sciences : CMLS · 2022
    Review
  4. Sleep Disruption and Cancer: Chicken or the Egg?Frontiers in neuroscience · 2022
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mariko SoDepartment of Health and Nutritional Care, Faculty of Medical Science, University of East Asia, Shimonoseki, 751-0807, Japan.
Hirofumi HashimotoDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Reiko SaitoDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Yukiyo YamamotoDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.
Yasuhito MotojimaDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Hiromichi UenoDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Satomi SonodaDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Mitsuhiro YoshimuraDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Takashi MaruyamaDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Koichi KusuharaDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.
Yoichi UetaDepartment of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan. yoichi@med.uoeh-u.ac.jp.
University of Occupational and Environmental Health Japan · JPUniversity of East Asia · JP

Funding

Grant-in-Aid for Research Activity Start-up 15H0680Grant-in-Aid for Scientific Research(C) 16k08537Grant-in-Aid for Scientific Research(C) 26461535
6 · The paper itself

Abstract

Orexin-A and -B, and ghrelin are potent orexigenic peptides. The effects of ACT462206, a novel dual orexin receptor antagonist (DORA), on ghrelin-induced feeding were examined in adult male Wistar rats. Hyperphagia induced by the intracerebroventricular (icv) administration of ghrelin was significantly suppressed for at least 2 h by pretreatment with icv administration of DORA. A marked increase was observed in the number of neurons showing Fos immunoreactivity in the paraventricular nucleus, arcuate nucleus and lateral hypothalamic area (LHA), 90 min after icv administration of ghrelin. Pretreatment with DORA significantly decreased the number of Fos-immunoreactive (IR) neurons; however, Fos immunoreactivity remained significantly increased. Double-immunostaining for Fos and orexin-A showed that many orexin-A-IR neurons in the LHA coexisted with Fos immunoreactivity after icv administration of ghrelin, but their number was reduced significantly by DORA pretreatment. These results suggest that centrally administered ghrelin may activate the orexinergic and non-orexinergic pathways responsible for the regulation of feeding.

Indexed as

AnimalsArcuate Nucleus of HypothalamusEatingGhrelinHypothalamic Area, LateralIntracellular Signaling Peptides and ProteinsMaleNeuronsNeuropeptidesOrexin Receptor AntagonistsOrexinsProto-Oncogene Proteins c-fosRatsRats, WistarGhrelinIntracellular Signaling Peptides and ProteinsNeuropeptidesOrexin Receptor AntagonistsOrexinsProto-Oncogene Proteins c-fosFood intakeFosGhrelinImmunohistochemistryOrexin receptor antagonist

Identifiers

PMID28054308
PMCPMC6394659
OpenAlexW2568473226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.